There are different yet scientific causes of peripheral neuropathy. If the patient underwent a severe traumatic event or injury, metabolic illnesses, severe infections, genetic or family history of certain diseases, and toxin exposure among the few. If you have diabetes or an account, it has a higher risk of acquiring a particular illness as well.
The peripheral nervous mechanism will send these signals coming from your spinal cord and brain to your whole body. Sensory information is sent by the peripheral nerves directly to your spinal cord or the central nervous mechanism.
Most people that have peripheral neuropathy will demonstrate that pain would likely be stinging to burning, sharp stabbing pain, and tingly sensations. The majority of occurrences, on the contrary, have better results after treatment and medications. Improve outcomes that are caused by treatable conditions pneumonitis and pain management through drugs.
Causes Of Nerve Problem
There is a myriad of reasons that may affect an individual to have peripheral neuropathy. There is no single illness that causes such medical conditions. However, there are a few health conditions that can lead to the development of peripheral neuropathy.
- Genetic disorders. Certain hereditary illnesses may cause an individual to develop peripheral neuropathy, Charcot-Marie-Tooth, to be specific, can be one of the high-risk causes.
- Diabetes. People with diabetes have a higher risk of developing peripheral neuropathy.
- Autoimmune illnesses. Diseases such as lupus, rheumatoid arthritis, Sjogren’s syndrome, Guillain-Barre syndrome, vasculitis, and chronic inflammatory demyelinating polyneuropathy, to name a few.
- Tumors that are malignant and benign. These include cancerous or the malignant ones, and noncancerous, which are harmless, may have developing stages when the press nerves or your nerves alone. One thing you have to remember about polyneuropathy may be a result of the body’s response to cancer treatment and development. This immune response is what we call paraneoplastic syndrome.
- Infections. Bacterial or viral infections such as HIV, leprosy, Hepa B and C, diphtheria, Epstein-Barr virus, Lyme disease, and shingles, to name a few.
- Illnesses related to bone marrow. Different bone marrow illnesses such as lymphoma, myeloma or bone cancer, and rare conditions such as amyloidosis.
- Other medical conditions. Illnesses such as liver, kidney, connective tissue illnesses, and hypothyroidism, or an inactive thyroid.
Some studies are a setback to your lifestyle, which later on can lead to neuropathy.
- Certain Vitamin deficiencies. If your body doesn’t have enough supply of vitamin E, niacin, and other B vitamins such as B-1, 6, and 12 to be exact.
- Toxic exposure. If you are exposed to hazardous substances and chemicals that may affect your health, such as mercury, lead, and other toxic industrial chemicals.
- Alcohol dependency. Vitamin deficiency can also be a significant cause of poor diet due to alcohol dependency, which later on can develop certain illnesses.
- Trauma or phobia. If you’ve had any severe or serious vehicular accidents that caused you to have cast, crutches, or injuries due to sports, which significantly damaged your nerves, the pressure from your nerve due to multiple motion routines like typing for a more extended time may damage your nerves over time too.
- Medications. Only a few categories, such as those medications related to cancer treatment or chemotherapy, may damage your nerves over time.
- However, there are no cases that can truly identify the direct cause of this illness.
Diagnosis And Treatment
There are a variety of causes when it comes to peripheral neuropathy. You can diagnose the cause through physical tests, which include blood exams, reviewed medical history, and neurological examinations.
Your physician will examine your muscle tone and strength. The tendon reflexes and how you respond to some sensations, together with physical coordination and posture, are among the exams for neurological diagnosis.
When it comes to reviewing your medical history, your physician will check common symptoms, toxin exposure, lifestyle, alcohol intake, and possible hereditary cases present in your bloodline.
The traditional test will enable your doctor to trace neuropathy by
- Image test. MRI and CT scans allow them to find herniated disks, abnormalities, and tumors.
- Blood exams. There are a variety of ways to detect illnesses with a tube of blood: Vitamin deficiencies, regular immune system functions, diabetes, and other indications, which can cause peripheral neuropathy.
- Nerve function exams. Advanced technology, such as EMG or electromyography, enables muscle nerve abnormalities. The electrode or thin needle will measure the electrical activity into your muscles when contract.
Your physician or EMG specialist will also conduct nerve tests. This will be done by placing flat electrodes on your skin. The low current of electricity will stimulate nerves. This process will be recorded by your doctor to check the nerves’ responses to electric current.
Skin biopsy, nerve biopsy, and other tests for your nerves will be done. Examinations for your sweat, reflex screen, and other sensory exams will further be done on how your body responds to these numbers of nerve tests.
The main goal for treatment is to help reduce and manage neuropathy. If you have negative results from your laboratory exams, your doctor may still monitor possible neuropathy developments over time.
There are a variety of procedures and therapies that enable the patient to alleviate symptoms or signs of peripheral Neurotherapy.
- Physical therapy enables you to strengthen your muscles. Improve movements, braces, walker, cane, or wheelchair for support may be needed.
- Plasma exchange is the method of cleansing your blood from antibodies and putting it back to you after the process. Immunoglobulins in the process of receiving antibodies through higher protein levels.
- You may undergo surgery if the cause of your neuropathy is nerve pressure. This can either remove the tumor or lessen the stress present to your nerves.
- TENS is the low level of electric current through electrodes placed into your skin. You can do this process 30 minutes a day for a whole month.
Medications not only cured neuropathy, but it also manages possible symptoms and signs from developing.
Antidepressants have significant benefits when it comes to managing pain as it interferes with the process, which helps control the feeling of pain. Drugs such as Pamelor (nortriptyline), Zonalon, Silenor (doxepin), and amitriptyline, to name a few tricyclic antidepressants.
Over the counter and anti-inflammatory nonsteroidal medications helps manage mild symptoms. Otherwise, your doctor may prescribe a higher dose of painkillers.
- A higher dose of painkillers is only prescribed when needed, as they can cause addiction and dependency. Those that contain opioids like tramadol (Ultram and Conzip) and drugs containing oxycodone like Roxicodone and Oxycontin, to name a few.
- Topical creams may contain ingredients usually found in red peppers. This helps manage peripheral neuropathy signs or symptoms. The burning sensation may, at times, lead to irritation. However, this will be manageable over time.
- Medications for anti-seizure helps manage nerve pain. One of the known setbacks for these types of drugs includes dizziness and drowsiness.
Lidocaine patches can be an alternative in managing nerve pain. Common side effects include numbness, dizziness, and drowsiness.
If peripheral neuropathy is the effect of diabetes, you can check with your doctor norepinephrine reuptake inhibitor duloxetine, serotonin, and venlafaxine. Though antidepressants can alleviate peripheral neuropathy, there are also known setbacks to these medications, such as decreased appetite, nausea, dizziness, drowsiness, constipation, and cause dry mouth.
Nerve Problem Normal Conditions
Whether you have been diagnosed with peripheral neuropathy or have a family history of the illness, lifestyle, and routine are important factors that may reduce or put your health at risk.
A healthy lifestyle, no matter how hard we may think of, is all about routine and proper mindset. It can start with a daily habit that can develop into a method and transform your lifestyle.
Exercising, choosing to eat healthily, and prevention are the essential secret of managing this specific condition. Include fruits and vegetables into your daily meal. Be mindful of what you eat. Food rich in protein improves nerve health, together with other healthy foods rich in nutritious stuff.
Exercising doesn’t mean you’ll have to sweat in the gym every day. You can set a specific time in the day to walk or do something that involves physical interaction.
Avoid adding pressure to your nerves. This includes checking posture, muscle movement, and repetitive motions. Prevent toxin exposure and other chemicals that are harmful to your health.
Risk Of Having Nerve Problem
There are essential factors that contribute to the development of peripheral neuropathy;
- Unhealthy lifestyle. Food intake and limited physical movement.
- Toxins exposure
- Repetitive motions
- Autoimmune illnesses
- Hereditary disease
- Vitamin deficiency (B Vitamins)
- Organ disorder
Common complications for most nerve problems include the following.
- Infections which reduce sensation to your body parts.
- Skin trauma and skin burns.
- Lack of physical balance.
When To Seek Medical Attention
Don’t hesitate to seek medical help immediately if you seem to have unusual pain, weakness, numb, blind or tingling in your feet and hands. The best way to prevent and treat peripheral neuropathy is by controlling the symptoms and being knowledgeable about the signs.
Table of Medications
The drug is used to cure and prevent osteoporosis among sufferers. It is likewise used among patients with Paget’s disease.
What is Alendronate?
Alendronate is an oral medicine that is available as a tablet, effervescent tablet, and oral solution. The medication is available as a branded drug under the name Binosto and Fosamax. It is also sold as a generic drug. Alendronate is used to cure osteoporosis and Paget’s disease among patients.
Usage of Alendronate
Alendronate is utilized to cure and treat osteoporosis. With this, your bones can turn weak and thin and easily break. The medicine can also cure Paget’s disease. In this ailment, the bones can become weak and soft, and eventually, it can become painful and all deformed as well as break easily. Alendronate is a valuable part of any combination therapy, which is potent when coupled with Vitamin D and Calcium supplements.
Alendronate – How It Works
Alendronate is a part of a class of drugs widely known as Bisphosphonates. It is a type of medicine that is a class of medications that work in the same way for muscle cramps. The drugs are used to treat osteoporosis and Paget’s disease. Alendronate works by inhibiting the sudden thinning and breakdown of the bone. This helps improve bone density and helps the bones stay strong and avoid breaking.
The most common Alendronate side effects are as follows:
If the effects are rather mild, they can go away quickly in a couple of days or weeks. But, if the symptoms are rather severe, or where they are severe, contact your doctor right away.
Alendronate Serious Side Effects
Contact your physician or pharmacist immediately if you experience any of the following serious side effects. Call for emergency medical assistance if you experience any life-threatening symptoms. The serious side effects of Alendronate are as follows:
Erosions or ulcers of the esophagus, the symptoms are as follows:
- Problem swallowing
- Pain when swallowing
- Chest pain
- Bloody vomit
- Bloody stools
Bone death of jaw. Here are the symptoms:
- Loosen teeth
- Swollen gums
- Poor healing of the jaw
- Heavy feeling in the jaw
Unusual breaking of bones in the legs and hips. It can include:
- Dull pain in the hips
- Pain in the groin
- Pain in the thigh area
Hypocalcemia or Low Calcium. The symptoms are:
- Numb fingers
- Numb toes
- Numbness in the mouth area
- Muscle cramps
- Severe joint pains
Dosage and Administration
The dosage information provided here is for the Alendronate tablet. The dosages and drug form may not be added here. The dosage, drug type, and how often the drug is taken will depend on the patients:
- Condition treated
- Severity of condition
- Other medical conditions
- How the patient reacts to the first dose
Dosage for Osteoporosis
- Variants of 5mg, 10mg, 35mg, 40mg, and 70mg
Alendronate Oral Solution
- 70 mg strength
Binosto Effervescent Tablet
- 70 mg strength
Adult Dosage (18 years and older)
- 70 milligrams once a week or 10 milligrams once a day for treatment
- 35 milligrams once a week or 5 milligrams once a day
Child Dosage (0–17 years old)
- The drug should not be used by individuals who are 18 years old and younger.
Different medications require different storage requirements. Always read the product label found on the packaging on how to properly store your Alendronate medication. Keep your medication away from pets and children’s reach at all times.
Never flush out your medication down the toilet or the drain unless when you are told to do so. Follow proper ways of discarding your medication found on the product packaging when no longer in need or when the product expires. Ask your doctor or pharmacist for proper waste disposal.
Alendronate tablet interacts with other medications, vitamins, or herbal supplements. The interaction occurs when a substance changes the way the medicine works. This can be dangerous and hinder the medicines from working well. To avoid any interactions, the physician will manage your medications. Make sure you inform your doctor about all the vitamins, supplements, and medicines you are taking. Check how the drug can interact with something you are taking.
Here are the drugs that can result in interactions with the Alendronate drug.
Interactions that can heighten side effects:
Taking Alendronate tablet with some drugs can result in more side effects, here is the list of these drugs:
- NSAIDs or non-steroidal anti-inflammatory drugs
You can have more upper gastrointestinal side effects like ulcers in our esophagus area. Ask the physician if it is safe for you to take these drugs.
Interactions can make the drug Alendronate less effective. Whenever used with some drugs, it cannot work well to treat your condition. Alendronate in the body can be decreased. Here are some drugs:
- Calcium supplements
The drugs mentioned above can reduce how the medication absorbs in the body. You should let at least 30 minutes to pass after taking your alendronate another oral medication.
Warnings and Precautions
Take this drug on an empty stomach with a glass of water. Never take with coffee, tea, juice, soda, or mineral water. Doing so can minimize the level of the drug’s potency in the body. It can also heighten certain side effects. Wait at least 30 minuted before you eat or drink something.
Alcohol can heighten the risk of some side effects on your stomach from taking alendronate. When you intend to drink alcohol, ask your doctor first about it. They can monitor and assess your stomach problems.
The medication alendronate can lead to some very severe allergic reactions. Symptoms of its side effects can include:
- Skin rashes
- Swollen face
- Swollen lips
- Swollen tongue
- Problems breathing
Whenever you experience any allergic reaction, call your doctor or the local poison center in your area without delay. When the symptoms you experience are rather severe, call for emergency medical assistance or dial 911. Never attempt to take this medication ever again if you have ever had any allergic reactions to the drug. Taking it once again can be dangerous and can even lead to death.
Warnings for Certain Users
For those with problems in their esophagus, never take this medication. You will be more likely to have severe side effects like erosions or ulcers in the esophagus area.
For patients with very low calcium blood levels, the physician must provide you calcium medications before starting to take this medicine. Taking Alendronate can only make your health condition worse.
For patients with severe kidney problems, well for those with kidney problems or a history of kidney ailment, you should not be able to clear this from your body. So, you should avoid taking Alendronate altogether.
For pregnant women, Alendronate is a regulated category C pregnancy drug. It can only mean two things:
- There are no enough studies made on humans to be sure how Alendronate can impact the unborn child.
- The research revealed that in animals, adverse effects occur to the fetus when the mother took the medication.
Always make sure to ask your doctor if you intend to become pregnant or already pregnant. The Alendronate can be used when the potential advantage justifies the risk to the unborn child.
Those who are breastfeeding must consult with their doctor first if they can use Alendronate while breastfeeding. It is not known whether Alendronate can pass into breast milk. When it does, it can lead to some serious side effects to the nursing baby. Ask your doctor or pharmacist if you are breastfeeding a baby and intend to take the medication. They will decide whether you should stop taking the medication altogether.
Senior citizen patients who have kidney problems or who have weakened kidneys must not take Alendronate too. This medication can lead the body to process certain medicines very slowly. This can result in other problems as the drug will stay in the body for an extended period, and it raises your risk to other side effects.
Pediatric patients are refrained from using this medication. It is not for use by patients 18 years old and below.
Overdose and Contraindications
When someone you know has overdosed or has severe symptoms like trouble breathing, passing out, or more, call a doctor or pharmacist for immediate medical assistance. You can also call on the poison control center immediately. Residents from the USA can call on their local poison control center for assistance. Severe symptoms of overdose can include persistent nausea, vomiting, diarrhea, stomach pain, or cramps. Never share this medication with another person even if they have symptoms similar to you.
The drug has been prescribed for your condition only. Never take any other pain reliever for your urinary tract problem unless you have consulted with your doctor. A different drug may be needed under this circumstance.