Propofol Side Effects

Propofol is a drug that reduces anxiety and tension, and promotes relaxation and sleep or loss of consciousness. Propofol provides loss of awareness for short diagnostic tests and surgical procedures, sleep at the beginning of surgery, and supplements other types of general anesthetics.

Propofol is for injection into a vein. It is given by trained anesthesia professionals in a controlled environment.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What drug(s) may interact with Propofol?

  • alcohol
  • barbiturate medicines for inducing sleep or treating seizures (convulsions)
  • herbal products, including St. John’s wort
  • medicines for anxiety or sleeping problems, such as diazepam or temazepam
  • medicines for colds, breathing difficulties, or weight loss
  • medicines for mental problems and psychotic disturbances
  • medicines for pain

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • difficulty breathing, wheezing, swelling of the throat
  • fast heartbeat, palpitations
  • lightheadedness or fainting spells
  • numbness or tingling in the hands or feet
  • seizure (convulsion)
  • skin rash, flushing (redness), or itching
  • swelling or extreme pain at the injection site
  • uncontrollable muscle spasm

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • dizziness
  • pain or irritation at the injection site
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