Prezista (darunavir) is a protease inhibitor. Darunavir is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.
Prezista is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). It is not a cure for HIV or AIDS.
You should not take Prezista if you are allergic to darunavir or ritonavir (Norvir, Kaletra), or if you have severe liver disease.
Some drugs can cause life-threatening side effects if you use them while you are taking Prezista.
Do not take Prezista with:
- alfuzosin (Uroxatral);
- cisapride (Propulsid);
- pimozide (Orap);
- lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync);
- rifampin (Rifadin, Rimactane, Rifater);
- sildenafil (Revatio);
- St. John’s wort;
- triazolam (Halcion) or oral midazolam (Versed); or
- ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).
To make sure Prezista is safe for you, tell your doctor if you have:
- liver disease (especially hepatitis or cirrhosis);
- a bleeding disorder such as hemophilia;
- high cholesterol or triglycerides; or
- if you are allergic to sulfa drugs.
FDA pregnancy category C. It is not known whether Prezista will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.
Get emergency medical help if you have any of these signs of an allergic reaction to Prezista: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Prezista and call your doctor at once if you have:
- the first sign of any skin rash, no matter how mild;
- signs of a new infection, such as fever or chills, cough, flu symptoms, easy bruising or bleeding;
- increased sweating, tremors in your hands, anxiety, feeling irritable, sleep problems (insomnia);
- diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;
- swelling in your neck or throat (enlarged thyroid);
- muscle weakness, tired feeling, joint or muscle pain, feeling short of breath;
- weakness or prickly feeling in your fingers or toes;
- severe lower back pain, loss of bladder or bowel control;
- problems with walking, breathing, speech, swallowing, or eye movement;
- severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
- nausea, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision); or
- severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Prezista side effects may include:
- mild nausea, vomiting, stomach pain;
- mild skin rash; or
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.