Modafinil Side Effects

Improving wakefulness in patients with excessive sleepiness associated with narcolepsy or other sleep disorders. It may also be used for other conditions as determined by your doctor.

Modafinil is a wakefulness-promoting agent. Exactly how it works is not known, but it is thought to work by altering the natural chemicals (neurotransmitters) in the brain.

Some medical conditions may interact with modafinil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems, kidney problems, heart problems (eg, chest pain, heart blood vessel problems, a recent heart attack), or high blood pressure
  • if you have a history of mental or mood problems (eg, depression, mania, psychosis), suicidal thoughts or actions, or alcohol or other substance abuse or dependence
  • if you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine)

Some MEDICINES MAY INTERACT with modafinil. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azole antifungals (eg, ketoconazole, itraconazole) because they may increase the risk of modafinil’s side effects
  • Carbamazepine, phenobarbital, prazosin, or rifampin because they may decrease modafinil’s effectiveness
  • Amphetamines or other stimulants (eg, methylphenidate), anticoagulants (eg, warfarin), diazepam, hydantoins (eg, phenytoin), propranolol, or certain tricyclic antidepressants (eg, clomipramine, desipramine) because the risk of their side effects may be increased by modafinil
  • Axitinib, certain benzodiazepines (eg, midazolam, triazolam), cabazitaxel, cyclosporine, hormonal products (eg, birth control pills, certain hormone replacements), or ulipristal because their effectiveness may be decreased by modafinil

This may not be a complete list of all interactions that may occur. Ask your health care provider if modafinil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; diarrhea; dizziness; headache; nausea; nervousness; stomach upset; stuffy nose; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); blisters on the inside of the eyes, nose, or mouth; chest pain; confusion; fast or irregular heartbeat; fever, chills, or sore throat; mental or mood changes (eg, aggression, agitation, anxiety, depression, exaggerated sense of well-being, hallucinations, irritability, nervousness); red, swollen, blistered, or peeling skin; severe or persistent headache; shortness of breath; suicidal thoughts or actions; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, stomach pain, yellowing of the skin or eyes); unusual bruising or bleeding; unusual tiredness or weakness.

 

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