Lialda Side Effects

The Side effects of Lialda  range from mild to severe. The following presents some of the significant effects that might potentially occur while consuming this drug.

CAS ID 89-57-6
PubChem CID 4075
ChEMBL Id 704
ChemSpider ID 3933
Molar mass 153.135 g/mol
Trade names Pentasa, Asacol, Apriso etc

Lialda is a brand-name prescription medication for the treatment of ulcerative colitis in adults like Apriso. Mesalamine is the generic version of it. This medicine is an expensive drug that is more popular than other prescription drugs in the aminosalicylates class of medicine. It works by blocking the activity of cyclooxygenase and lipoxygenase, which reduces the production of prostaglandins.

Ulcerative colitis is an inflammatory bowel disease that may result in long-term ulcers and inflammation in the digestive tract. The disease affects the innermost lining of the large intestine and rectum. Signs and symptoms of the disease usually develop over, instead of developing suddenly. 

Ulcerative colitis can be a debilitating condition and may, at times, lead to life-threatening complications. Ulcerative colitis has no known cure but treatment can greatly reduce its signs and even bring about long-term remission.

Signs and symptoms

The symptoms of ulcerative colitis vary, depending on the severity of the inflammation and where it occurs. The signs and symptoms of ulcerative colitis may include:

  • Abdominal cramping and pain
  • Diarrhea, often with pus or blood
  • Rectal pain
  • Urgency to defecate
  • Rectal bleeding – passing a small amount of blood with stool
  • Weight loss
  • Inability to defecate despite urgency
  • Fever
  • Fatigue
  • In children, failure to grow

Most people with ulcerative colitis have mild to moderate symptoms. The course of ulcerative colitis varies, with some individuals having long periods of remissions.

Types of ulcerative colitis

Ulcerative colitis is classified by doctors according to location. The types of ulcerative colitis include:

  • Ulcerative proctitis – It is confined to the area of the colon that is closest to the rectum. Rectal bleeding could be the only sign of the disease. This type of ulcerative colitis is the mildest.
  • Proctosigmoiditis – It of ulcerative colitis involves the rectum and sigmoid colon – the lower end of the colon. The signs of this type of ulcerative colitis include bloody diarrhea, abdominal pain and cramps, and an inability to move the bowel despite the urge to do so.
  • Left-sided colitis – It of ulcerative colitis extends from the rectum up through the sigmoid and descending colon. The signs of this type of ulcerative colitis include abdominal pain and cramping, bloody diarrhea, and pain on the left area, and unintended weight loss.
  • Pancolitis – This type of ulcerative colitis affects the entirety of the colon and can cause episodes of bloody diarrhea that may be severe, abdominal pains and cramps, significant weight loss, and fatigue.
  • Acute severe ulcerative colitis – This rare form of ulcerative colitis affects the entire colon and causes severe pain, bleeding, profuse diarrhea, inability to eat, and fever.

What does mesalamine do to the body?

Mesalamine is a drug used for the treatment of ulcerative colitis and mild to moderate Crohn’s disease. Its exact mechanism of action is not fully understood but is believed to by reducing the inflammation in the colon. 

Ulcerative colitis and similar inflammatory diseases may cause excessive production of prostaglandins and other chemicals that cause problems in the colon. Prostaglandins are produced by the enzyme’s lipoxygenase and cyclooxygenase. These two enzymes are overactive in people with ulcerative colitis. 

Mesalamine may work by blocking the activity of the two enzymes – cyclooxygenase and lipoxygenase – which reduces the production of prostaglandins. When the production of prostaglandins is decreased it also decreases the inflammation in the colon and the signs that are typically associated with ulcerative colitis. Different forms of mesalamine differ in their route of administration and the frequency of the administration. 

Is Lialda a steroid?

Beginning in the 1950s, corticosteroids have been the traditional treatment for ulcerative colitis. Steroids have been proven to put this disease in remission. However, steroids do come with problems. About half of patients taking steroids, such as prednisone, for ulcerative colitis experience a reaction. Steroid use in ulcerative colitis can cause unwanted weight gain, acne, a moon face, insomnia, and irritability. 

Using steroids for three months, even at the very low dosages, can affect bone strength, which increases the risk of osteoporosis. Continued use of the steroid has many adverse effects, such as impaired healing, increase blood pressure, and steroid-induced diabetes.

Ulcerative colitis requires maintenance medicine. Such medicine should not be a steroid, which makes Lialda the drug of choice for the condition. It is not a steroid so it can be used long-term. 

Can Lialda cause kidney problems

Lialda or mesalamine is one of the safest drugs for the treatment of ulcerative colitis. It may occasionally cause diarrhea to get worse, and rarely some hair loss. Very rarely, mesalamine may cause kidney and liver damage. Fortunately, it is reversible when the use of the drug is stopped. 

The drug may cause a serious reaction, including kidney problems. When taking it, especially long-term, you should have your kidney and liver blood tests periodically. Even with the possible effects, the benefits of melamine outweigh the risk.

Side Effects

As with any medicine, Lialda could have some unwanted aftereffect. It is helpful to know these effects that were reported in the clinical studies of the drug. 

Seek emergency medical assistance if you experience any signs of an allergic reaction, such as difficulty hives, breathing, swelling of the face, lips, tongue, or throat. 

Stop taking the medicine and call your doctor immediately if you have:

  • skin rash, headache, fever
  • severe stomach pain, bloody diarrhea, cramping
  • signs of kidney problems, including painful or difficult urination, feeling tired, little or no urination, swelling in the ankles or feet, feeling tired, and shortness of breath
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • signs of liver problems such as appetite loss, tiredness, upper stomach pain, easy bruising or bleeding, clay-colored stools, dark urine, jaundice

The common side effects include:

  • headaches
  • back pain
  • flu-like signs
  • stuffy or runny nose, sinus pain, sore throat
  • rash
  • stomach pain, nausea, constipation, diarrhea, or excessive gas
  • abnormal liver function tests

Other reactions may occur. Report to your doctor or anyone who can provide medical advice diagnosis if any aftereffect may be associated with your use of Lialda and put your health at risk. Know what are the rights solution if these reactions happen.

More common ones

  • Unnatural results in liver function tests, which could be a cure for liver problems
  • flatulence or increase in passing gas
  • Loss of appetite
  • Headache
  • regressing symptoms of ulcerative colitis like diarrhea or stomach pain

The majority of these points reported being subsided after a couple of days or weeks. However, if they’re more severe or don’t subside, consult your physician or doctor immediately about a mesalamine effect. They can give you the best health advice diagnosis or treatment regarding this matter.

Serious and uncommon side effects

  • Live complications such as liver failure among patients who already developed liver problems.
  • severe allergic reaction
  • kidney problems like kidney failure
  • mesalazine also include induced acute intolerance syndrome
  • hair loss
  • Asacol 
  • Pentasa

Though serious Lialda mesalamine side effects are uncommon, they can still happen. Call your doctor immediately if you experience any of these uncommon points. 

More details

This FDA approved prescription drug with tablet delayed release can also cause an allergic reaction. Common signs associated with a mild allergic reaction with tablet delayed release include:

  • cause skin rash
  • flushing – redness, and warmth in your skin
  • itchiness

A much severe allergic reaction is not shared. However, it is possible. Here are the common signs of a severe allergic reaction:

  • breathing problem
  • sore throat
  • swelling of mouth and tongue
  • swelling under the skin, usually in the lips, eyelids, feet or hands

Allergic reactions linked to the heart have also been discovered with the drugs. Pericarditis of the heart muscle and myocarditis or swelling of the lining of the heart are some of the common cases. Signs include:

  • chest pain
  • abnormal heartbeat
  • breathing problems

If you feel anything unusual reported or not rights while taking Lialda mesalamine or apriso, it is best to consult your doctor immediately so they can give you an advice diagnosis or treatment for your health. Medicine reacts differently to different people and this is why you may not have the same reaction or experience with it as other people. It may be because of some pre-existing conditions or you may be more sensitive to this drug than others. Either way, get expert medical attention to prevent further effects or adverse reactions that might put your health at risk.

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