Here are cautions that you should be aware of when taking Lialda and other mesaline-based drugs:
- Coagulation abnormalities, ulfasalazine hypersensitivity, pyloric stenosis, and renal insufficiency.
- Do not take with lactulose or any drug with lower intestinal pH.
- Use with caution if you have severe renal failure or active peptic ulcer disease.
- Even if pericarditis is not common, watch out for breathing problems or chest pain
- Liver failure might happen, especially among patients with underlying live problems
- Rectal issues and low sperm concentration has been discovered among males.
- Worsening of inflammatory bowel disease or colitis after initial therapy
- Renal impairment such as renal failure, minimal change nephropathy, and chronic and acute interstitial nephritis reported.
- Risks among patients with renal impairment or consuming nephrotoxic drugs.
- Acute intolerance syndrome might happen; symptoms might be hard to determine uniquely if it’s from an ulcerative colitis exacerbation; look out for aggravating symptoms; stop using if you suspect acute intolerance syndrome.
- Hypersensitivity reactions like pericarditis and myocarditis discovered; inspect patients right away and stop taking the drug if hypersensitivity reaction is determined.
Pregnancy and Breastfeeding
- Use with caution if you are pregnant, especially if the advantages outrank the risks.
- Mesalamine passes through the breast milk, talk to your doctor before taking the medication of you are lactating.
Overdose and Contraindications
Lialda is considered as an aminosalicylate, and some of the symptoms of salicylate overdosage includes confusion, sweating, headache, drowsiness, hyperventilation, dyspnea, seizures, vomiting, vertigo, diarrhea, and tinnitus. Extreme overdosage can result in unbalanced blood pH and electrolyte, as well as dehydration, hyperthermia, and end-organ hazards. Keep Lialda away from children. In the event of overdose, look for immediate help or call a Poison Control Center right away. Here are the contraindications when taking Lialda:
- Hypersensitivity to salicylates or mesalamine
- Children with flulike symptoms and chickenpox
- Rectal suspension: hypersensitivity to aminosalicylates, salicylates, or any ingredients found in the suppository vehicle
When it comes to the mechanism of action of Lialda, the whole concept is not yet fully understood. However, this drug tends to deliver topical anti-inflammatory impact on the colonic epithelial cells. Generally, the mucosal production of the cyclooxygenase acid metabolites passes through the lipoxygenase and cyclooxygenase passages. An increase can be experienced among those with chronic inflammatory bowel disease, and there is a possibility that the mesalimine can remove inflammation by impeding cyclooxygenase and preventing the production of prostaglandin in the colon.
The recommended dosing when it comes to the induction among adult patients that have active and mild to moderate ulcerative colitis is 2-4 1.2 g Lialda tablets consumed daily with food for an overall regular dose of 4.8 g or 2.4 g. On another note, the suggested dosing for the maintenance of ulcerative colitis is 2 1.2 g of Lialda tablets taken regularly with food for a general dose of 2.4 g. If you are planning to take Lialda, always talk to a healthcare professional such as your doctor or physician first. They will give you appropriate advice diagnosis or treatment for your ulcerative colitis.