Get emergency medical help if you have any of these signs of an allergic reaction to ESTROGEL: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using ESTROGEL and call your doctor at once if you have a serious side effect such as:
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- sudden numbness or weakness, headache, confusion, or problems with vision, speech, or balance;
- pain, swelling, warmth, or redness in one or both legs;
- abnormal vaginal bleeding;
- pain, swelling, or tenderness in your stomach;
- jaundice (yellowing of the skin or eyes); or
- a lump in your breast.
Topical estradiol is absorbed through the skin and can cause premature puberty in a child who comes into contact with this medicine or with skin where the medicine was applied. Call your doctor if a child who has close contact with you develops swollen nipples or enlarged breasts.
Less serious ESTROGEL side effects may include:
- nausea, vomiting, loss of appetite;
- swollen breasts;
- acne or skin color changes;
- vaginal pain, dryness, or discomfort, decreased sex drive, or difficulty having an orgasm;
- swelling, weight gain;
- migraine headaches, dizziness, depression; or
- break-through bleeding, vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.