Enoxaparin Side Effects

Preventing blood clots in patients who have certain illnesses or who will be having certain types of surgery. It is also used along with other medicine to treat blood clots. It is also used along with other medicine to prevent certain problems caused by heart attack or unstable angina (chest pain). It is also used to decrease the risk of recurring heart attack in certain patients. It may also be used for other conditions as determined by your doctor.

Enoxaparin is a low molecular weight heparin (LMWH). It works by blocking the formation of blood clots.

Do not use Enoxaparin if:

  • you are allergic to any ingredient in enoxaparin
  • you are allergic to heparin, benzyl alcohol, or pork products
  • you have severe or uncontrolled high blood pressure, or active major bleeding
  • you are taking a salicylate (eg, aspirin) or an NSAID (eg, ibuprofen, naproxen)
  • you have a low platelet count and the presence of antiplatelet antibodies

Contact your doctor or health care provider right away if any of these apply to you.


Some medical conditions may interact with enoxaparin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney problems, liver problems, stomach or intestinal problems (eg, ulcers), stroke, or vision problems caused by diabetes
  • if you have inflammation of the heart due to a bacterial infection; severe, uncontrolled high blood pressure; low body weight; or have a mechanical prosthetic heart valve
  • if you have a bleeding disorder, a history of brain bleeding or blood conditions, or von Willebrand disease
  • if you have recently had or are scheduled to have brain, spine, or eye surgery, an epidural catheter, or a spinal puncture
  • if you are taking medicines that affect platelets (eg, aspirin, clopidogrel, ticlopidine)
  • if you have a history of low platelet counts or bleeding problems after taking heparin
  • if you have recently given birth

Some MEDICINES MAY INTERACT with enoxaparin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Activated protein C, anticoagulants (eg, warfarin), dextran, dipyridamole, direct factor XA inhibitors (eg, rivaroxaban), direct thrombin inhibitors (eg, dabigatran), injectable cephalosporins (eg, cephazolin), injectable penicillins (eg, ampicillin), NSAIDs (eg, ibuprofen, ketorolac, naproxen), platelet inhibitors (eg, clopidogrel, ticlopidine), salicylates (eg, aspirin), sulfinpyrazone, or thrombolytics (eg, streptokinase) because the risk of side effects, such as bleeding, may be increased
  • Nitrates (eg, nitroglycerin) because they may decrease the effectiveness of enoxaparin

This may not be a complete list of all interactions that may occur. Ask your health care provider if enoxaparin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; mild pain, irritation, swelling, redness, bleeding, or bruising at the injection site; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, or tarry stools; confusion; difficulty walking; fainting; fever; pale skin; pink or red urine; severe or persistent dizziness, tiredness, or weakness; swelling; tingling, numbness (especially in the legs and feet), and muscle weakness; unusual bleeding or bruising; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.