Duexis Side Effects

Duexis contains a combination of famotidine and ibuprofen. Famotidine is a histamine blocker. Famotidine works by decreasing the amount of acid the stomach produces.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Duexis is a combination drug used to treat osteoarthritis and rheumatoid arthritis. Ibuprofen treats the symptoms of arthritis. Famotidine helps reduce the risk of ulcers in the stomach or intestines that can be caused by long-term use of ibuprofen.

Do not use Duexis just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning, especially in older adults.

You should not use Duexis if you are allergic to ibuprofen (Advil, Motrin) or famotidine (Pepcid), or if you have:

  • a history of asthma, hives, or severe allergic reaction after taking aspirin or another NSAID, such as naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
  • if you are allergic to other stomach acid reducers such as ranitidine (Zantac), cimetidine (Tagamet), or nizatidine (Axid); or
  • if you are more than 29 weeks (7 months) pregnant.

To make sure you can safely take Duexis, tell your doctor if you have any of these other conditions:

  • Crohn’s disease, inflammatory bowel disease, or ulcerative colitis;
  • a history of heart attack, stroke, or blood clot;
  • heart disease, congestive heart failure, high blood pressure;
  • a history of stomach ulcers or bleeding;
  • asthma;
  • polyps in your nose;
  • liver or kidney disease;
  • systemic lupus erythematosus (SLE);
  • a bleeding or blood clotting disorder; or
  • if you smoke.

Famotidine and ibuprofen can pass into breast milk and may harm a nursing baby. Do not use Duexis without telling your doctor if you are breast-feeding a baby.

FDA pregnancy category C. Do not take Duexis if you are more than 7 months pregnant. Taking ibuprofen during this time may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Duexis. Do not give Duexis to a child without the advice of a doctor.

Get emergency medical help if you have any of these signs of an allergic reaction to Duexis: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Duexis and seek medical attention or call your doctor at once if you have any of these serious side effects:

  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • sweating, trouble breathing, chest pain or discomfort that may spread to the arm, shoulder, back, or jaw;
  • feeling short of breath, even with mild exertion;
  • swelling or rapid weight gain;
  • urinating less than usual or not at all;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • severe skin reaction – fever, sore throat, redness or swelling in your face, redness or swelling of your hands or feet, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • bruising, severe tingling, numbness, pain, muscle weakness; or
  • severe headache, neck stiffness, chills, increased sensitivity to light, and/or seizure (convulsions).

Less serious Duexis side effects may include:

  • upset stomach, vomiting, diarrhea, constipation;
  • bloating, gas;
  • headache;
  • throat irritation;
  • blurred vision, changes in color vision; or
  • mild back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.