Tadalafil side effects and drug information

Tadalafil is an oral med consumed by users for the reason that it heightens blood flow in certain parts of the body and relaxes the muscles of the blood vessels. Tadalafil is the Cialis generic name, which is utilized to cure impotence or erectile dysfunction, symptoms of an enlarged prostate or benign prostate hypertrophy with urination troubles, and pulmonary arterial hypertension. It is an oral tablet. Typically, the effect starts after 30 minutes of taking the drug and lasts for 36 hours.

Trade names Tadacip, Adcirca, Adcirca etc
PubChem CID 110635
ChemSpider ID 99301
Protein binding 94%
Molar mass 389.404 g/mol
CAS ID 171596-29-5

Tadalafil side effects and drug information

Tadalafil belongs to the category of drugs known as phosphodiesterase type (PDE5) inhibitors. PDE5 inhibitors are a category of drugs that made of a group of medications that function similarly. These meds are usually utilized to cure the same medical condition. As aforementioned, Tadalafil assists in relaxing the muscle in your bladder and prostate, which could help alleviate symptoms of Benign Prostate Hypertrophy or BPH. On another note, the meds also improve blood flow towards the penis, which can significantly help in maintaining an erection that enhances the symptoms of Erectile Dysfunction or ED. However, for Cialis to successfully assist you in achieving an erection, you need to be sexually aroused. In terms of Pulmonary Arterial Hypertension or PAH, the meds enhances your capacity to exercise by calming the blood vessels located in your lungs, which results in increased blood flow.

Side Effects

Tadalafil side effects don’t typically lead to drowsiness. However, it can result in other side effects.

Common side effects

The most common side effects that patients might experience when with Cialis are:

  • headache
  • back pain
  • upset stomach
  • flushing (reddish skin)
  • muscle aches
  • stuffy or runny nose
  • diarrhea

In the case that these side effects are mild, expect that they will subside after several days or a few weeks. However, if they are more severe or don’t instantly sink, ask help from healthcare professionals.

Severe side effects

Contact healthcare professionals immediately if you suffer from severe side effects from taking Cialis. If the symptoms are already life-threatening or if you have a medical emergency, reach out to 911 right away. Severe side effects and symptoms include the following:

1. Priapism among men

  • an excruciating erection that doesn’t seem to subside

2. Vision changes

  • problem seeing the difference between colors green and blue
  • seeing a shade of blue when looking at things
  • dramatic and instant reduction or loss of vision in one or both eyes

3. Hearing loss

  • ringing in the ears
  • immediate decrease or loss in hearing
  • dizziness

4. Low blood pressure

  • fainting
  • dizziness or lightheadedness
  • chest pain or angina

Take note that Tadalafil affects every person in a different way. Thus you can’t guarantee that these are all the side effects that you could experience if you take medicine. Moreover, this information does not substitute for advice about the side effects of Tadalafil It is still important to rely on your doctor for medical advice. They are fully aware of your complete medical history, so they know the potential side effects that you might experience.

Indication and dosage

Erectile Dysfunction

Indicated for the cure of erectile dysfunction or ED:

  • PRN use: taking 10 mg of Tadalafil initially before sexual intercourse, with or without food; can be increased to 20 mg or lowered to 5 mg depending on the tolerability or efficacy; in many patients, the optimum dosage is one tablet per day.
  • Once-daily use: 2.5 mg/day of Tadalafil in once-daily dose, regardless of the timing of sexual intercourse, with or without food; can be increased to 5 mg/day depending on the tolerability and efficacy.

Benign Prostatic Hyperplasia

Indicated for the treatment of symptoms and signs of benign prostatic hyperplasia (BPH):

  • BPH: 5 mg of Tadalafil daily
  • BPH with ED: 5 mg of Tadalafil daily, consumed exactly at a similar time every day regardless of the timing of sexual intercourse.

Pulmonary Arterial Hypertension

Indicated for pulmonary arterial hypertension (PAH) to increase the ability to exercise:

  • PAH: 40 mg of Tadalafil daily
  • PAH patients consuming ritonavir: 20 mg of Tadalafil daily

Drug Interaction

Tadalafil might interact with other types of meds, herbs, and vitamins that the patient is consuming. Get medical advice diagnosis or treatment before taking meds. Interaction happens when a particular substance alters the manner of how the drug functions. This reaction could be hazardous or prevent the drug from taking its action. To avoid Tadalafil interactions, your doctor should manage every meds that you take correctly. Make sure you inform your doctor about all the medicines, herbal supplements, and vitamins that you are consuming. Consult with your pharmacist or doctor to determine how Cialis interacts with other drugs.

Here are several medications that can result in interactions with Tadalafil :

Angina drugs (nitrates)

If you consume Tadalafil alongside nitrates, there’s a possibility that your blood pressure will suddenly raise decrease to an abnormal level. It could lead to dizziness or cause you to faint. Below are examples of nitrates:

  • isosorbide dinitrate
  • amyl nitrite
  • nitroglycerin
  • isosorbide mononitrate
  • butyl nitrite

High blood pressure or prostate drugs (alpha-blockers)

If you consume Tadalafil with a particular type of alpha-blockers, there’s a risk that your blood pressure will suddenly decrease to an insanely low level, which is very dangerous. It could lead to dizziness or cause you to faint. Below are examples of alpha-blockers:

  • alfuzosin
  • terazosin
  • doxazosin
  • tamsulosin
  • prazosin

Several HIV drugs

Consuming Tadalafil with particular HIV drugs can dramatically heighten levels of Tadalafil in your blood. Typically, it could result in fainting, dizziness, low blood pressure, and vision troubles. Among men, it could develop to priapism. Protease inhibitors include:

  • ritonavir
  • lopinavir/ritonavir

Oral antifungal drugs

Consuming antifungal drugs alongside Tadalafil might surge the Tadalafil levels in your blood. Typically, it could result in fainting, dizziness, low blood pressure, and vision troubles. Among men, it could develop to priapism. Oral antifungal drugs include:

  • ketoconazole
  • itraconazole


Consuming antibiotics alongside Tadalafil might upsurge the Tadalafil levels in your blood. Typically, it could result in fainting, dizziness, cause low blood pressure, and vision troubles. Among men, it could develop to priapism. Antibiotics include:

  • erythromycin
  • clarithromycin
  • telithromycin

Other kinds of antibiotics might decrease the Tadalafil levels in your blood and could impede the medication from working correctly. These antibiotics include:

  • rifampin

Other erectile dysfunction (ED) drugs

These are the kinds of medications that work just like Tadalafil . However, if you consume them together with Tadalafil , it might heighten the risk of experiencing side effects. Other ED drugs include:

  • sildenafil
  • vardenafil

Other pulmonary arterial hypertension (PAH) drugs

Taking Tadalafil together with other kinds of PAH drugs might lead to decreased blood pressure that is extremely dangerous. Other PAH drugs include:

  • Ocicat

Stomach acid drugs

If you take drugs for stomach acids with Tadalafil , it might prevent your body from absorbing Tadalafil properly. Stomach acid drugs include:

  • magnesium hydroxide/aluminum hydroxide

Epilepsy drugs

Consuming particular anti-seizure drugs alongside Tadalafil might decrease the level of Tadalafil in your blood. This prevents Tadalafil from working properly. Epilepsy drugs include:

  • carbamazepine
  • phenytoin
  • phenobarbital

Always keep in mind that no matter how relevant this information is, it is still best to contact your doctor to provide medical advice diagnosis. Cialis or Tadalafil has plenty of side effects and interactions, so make sure that before taking the medication, talk to a healthcare professional first. Inform them about the herbal supplements, vitamins, prescription drugs, and over-the-counter medicines that you are taking. Conferring with a healthcare professional about possible reactions, advice diagnosis or treatment will help you decrease the risk of suffering from interactions and even pain when using Cialis or Tadalafil.

Tadalafil Warnings and precautions

Patients shouldn’t consume Cialis or Tadalafil for more than once in 24 hours. They also need to be sexually aroused for the medication to take effect. Always bear in mind that Cialis doesn’t work like magic. It doesn’t cause an instant erection without specific stimulation. Men who take Cialis needs to be fit and healthy to have sex. They shouldn’t choose any nitrates that are intended for angina or chest pain when using Cialis or Tadalafil. Moreover, if an erection doesn’t subside after more than four hours or pain is already felt along with it, consult a doctor right away so he can provide medical advice diagnosis as well as explain advice about side effects.

Furthermore, other warnings are associated with taking Cialis or Tadalafil :

Allergy warning

Cialis or Tadalafil can lead to a severe allergic reaction. Some of the symptoms are:

  • problems with breathing and swallowing
  • rash and eye pain
  • swelling of your throat, lips, or tongue
  • cause hives

If you acquire the following symptoms, especially pain, immediately contact 911 or head to the nearest hospital. Don’t consume Tadalafil again if you already suffered from an allergic reaction. Consuming Tadalafil still is fatal and could lead to death.

Grapefruit interaction warning

Drinking grapefruit juice or eating grapefruit might heighten the levels of Cialis or Tadalafil in your blood. It increases the risk of side effects s its part of the directions precautions to consider before taking the FDA approved meds.

Alcohol interaction warning

As much as possible, avoid drinking vast amounts of alcoholic beverages if you are under the influence of Cialis. Combining Cialis and alcohol can widen or dilate your blood vessels and can result in decreased blood pressure.

Warnings for patients with specific health conditions

Heart disease warning: Sexual intercourse can put your heart at risk, and consuming Cialis or Tadalafil will even raise this risk. If you have a heart condition advised to stay away from any sexual activity, then you should also not use Cialis.

Prolonged erection warning: Cialis can potentially lead to priapism. It is a condition that results in painful, long-term erection of the penis. Priapism is considered a medical emergency and a whole lot of pain. Consult your doctor before taking Cialis or Tadalafil if you are suffering from a complication that could increase your risk of priapism. These health complications include:

  • Blood cell problems like multiple myeloma, sickle cell anemia, or leukemia
  • Peyronie’s disease – a deformed or curved penis

Vision or eye problems warning: Retinitis pigmentosa is a rare genetic eye illness. There has been no research on the effects of Cialis or Tadalafil to people with this condition. But it is highly recommended that they shouldn’t consume it. Talk to your doctor if you have ever had severe vision loss, such as non-arteritic anterior ischemic optic neuropathy or NAION. If you drink Cialis and you’ve had NAION, there’s a chance that you’ll develop it again.

Dialysis and kidney disease warning: your body might be unable to remove Cialis or Tadalafil properly, resulting in the medication remaining in your body for a prolonged period. Prolonged retention can increase your risk of side effects. If you have kidney disease, your physician might begin giving you a low dosage or not at all.

Liver problems warning: if you have a liver complication, it might be difficult for your liver to absorb Cialis or Tadalafil properly, and the medication will remain in your body for a prolonged period, increasing side effect risks. If you have liver problems, your physician might begin giving you a low dosage or not at all.

Peptic ulcers and bleeding disorders warning: There has been no research on the side effects of Cialis among those with these conditions. However, taking Cialis and Tadalafil might worsen or cause ulcers or bleeding. Your doctor will keep a close eye on you if you are taking Cialis or Tadalafil and you have bleeding disorder or ulcer.

Warnings for other groups of users

Pregnant women warning: according to studies of Cialis or Tadalafil among pregnant animals, the results showed zero side effects to the fetus. But there haven’t been sufficient studies that involve pregnant women consuming the meds for PAH to display whether or not it poses high risks among the human fetus. If you are pregnant or planning to get pregnant, reach out to your doctor for directions precautions.

Breastfeeding women warning: Cialis is notorious for being able to mix with breast milk. When this happens, breastfed children might experience severe side effects. Make sure you talk to your doctor if you are using Cialis and breastfeeding at the same time.

Seniors warning: For patients who are 65 years old or more, their body might absorb this meds slower. With this, the directions that your doctor will give seniors is to take Cialis is small doses to prevent drug accumulation in the body. Extreme levels of Cialis in the collection are considered harmful and some patients experience muscle pain or another form of pain in the eye, arms or legs.

Children warning: Children lower than 18 years old isn’t advisable to take Cialis. There are no studies that can claim that it is safe and effective among children.

Overdose and Contraindications

Confer with a doctor or physician if you are experiencing pain and numbness during sexual activity. If you are suffering from sudden vision loss due to the fact that Cialis can lower the flow of blood towards the optic nerve in your eye, get emergency help right away. Do not worry if you missed your dose of Cialis. There is no specific dose schedule for Cialis. You can consume it as needed. However, don’t ever take an additional tablet to make up for the missed doses, since this could lead to overdose.

Clinical Pharmacology

Cialis is a treatment for male erectile dysfunction or impotence, as well as pulmonary arterial hypertension or PAH. Generally, the physiological procedure of the erection of the penis involves the secretion of nitric oxide or NO in the corpus cavernosum. After this, the guanylate cyclase enzyme is activated, which improves cyclic guanosine monophosphate (cGMP) levels. Higher cGMP levels result in an enhanced inflow of blood and successful erection of the penis. Cialis is a unique and robust inhibitor under cGMP specific phosphodiesterase type 5 (PDE5), which means that it facilitates the degradation of cGMP in the corpus cavernosum. When Cialis is inside the patient’s body, regular sexual stimulation results in improved amounts of cGMP in the corpus cavernosum and leads to greater erections. But, when sexual stimulation and NO/cGMP system activation is absent, Cialis cannot cause a successful erection.

Medication Guide

Alongside the need to take Cialis is a responsibility that you should consume it properly. Don’t divide the Cialis tablets. You should drink the whole dose. You can also take Cialis on an empty stomach. Here are other considerations that you should take note:

Cialis for Erectile Dysfunction

The recommended initial dosage of Cialis for patients who use it as needed is 10 mg, consumed according to anticipated sexual activity. However, the dose might be raised to 20 mg or lowered to 5 mg, depending on personal tolerability and efficacy. The optimum dosage recommended is one tablet daily. Also, taking Cialis when needed was discovered to enhance erectile function than using a placebo for up to 36 hours, as long as you follow the correct dosage. If you want to achieve the maximum effects of Cialis, consume it with consideration. On the other hand, the recommended initial dosage of Cialis for everyday use is 2.5 mg, drunk at a consistent time daily, regardless of the timing of sexual activity. Dosage of Cialis for once a day use might be raised to 5 mg, depending on your tolerability and efficacy.

Cialis for Benign Prostatic Hyperplasia

The recommended dosage of Cialis for patients who take it once a day is 5 mg, consumed at a consistent time daily. If the patient undergoes therapy and takes finasteride alongside Cialis, the prescribed dosage for once a day is 5 mg, drunk at a regular time daily for as much as 26 weeks.

Cialis for once a day use for Benign Prostatic Hyperplasia and Erectile Dysfunction

The recommended dosage of Cialis for patients who consume it once a day is 5 mg, drunk at a consistent time daily, regardless of the timing of sexual activity.

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