|Molar mass||153.135 g/mol|
|Trade names||Pentasa, Asacol, Apriso etc|
Lialda or Mesalamine is a brand name prescription medication that impacts the substance found in the human body that is responsible for tissue damage, inflammation, and diarrhea. It is known as an anti-inflammatory medication that is utilized to cure ulcerative colitis, proctosigmoiditis, and proctitis.
It is also prescribed to keep the symptoms of ulcerative colitis at bay and stop it from recurring. Lialda is utilized in two methods to cure ulcerative colitis: induction of remission and maintenance of remission. Induction of remission means causing a reduction. Lialda mesalamine heals mild to moderate symptoms associated with ulcerative colitis until they go away, and the patient gets well. On the other hand, maintenance of remission means maintaining you in remission. Lialda helps patients stay free from symptoms associated with ulcerative colitis. Different brand-name versions of Lialda include Apriso, Asacol HD, Pentasa, and Delzicol. These prescribed drugs are approved by the Food and Drug Association or FDA but still require a doctor for advice diagnosis or treatment.
Lialda side effects range from mild to severe. The following common side effects present some of the significant effects that might potentially occur while consuming Lialda.
More common side effects:
- Unnatural results in liver function tests, which could be a cure for liver problems
- flatulence or increase in passing gas
- Loss of appetite
- regressing symptoms of ulcerative colitis like diarrhea or stomach pain
The majority of these side effects subside after a couple of days or weeks. However, if they’re more severe or don’t subside, consult your physician or doctor immediately about mesalamine side effects
Serious side effects:
- Live complications such as liver failure among patients who already developed liver problems.
- severe allergic reaction
- kidney problems like kidney failure
- mesalazine side effects also include induced acute intolerance syndrome
- hair loss
Though serious lialda mesalamine side effects are not common, they can still happen. Call your doctor immediately if you experience any of these side effects.
More details about asacol side effects:
This FDA approved prescription drug with tablet delayed release can also cause an allergic reaction. Symptoms associated with a mild allergic reaction include:
- skin rash
- flushing – redness, and warmth in your skin
A much severe allergic reaction is not shared. However, it is possible. Here are the symptoms of an allergic reaction that’s severe:
- breathing problem
- sore throat
- swelling of mouth and tongue
- swelling under the skin, usually in the lips, eyelids, feet or hands
Allergic reactions linked to the heart have also been discovered with Lialda. Pericarditis or inflammation of the heart muscle and myocarditis or swelling of the lining of the heart are some of the common cases. Symptoms include:
- chest pain
- abnormal heartbeat
- breathing problems
Indication and Dosage
Lialda is an indication for induction of ulcerative colitis remission and maintenance for it. Your doctor or physician will provide medical advice diagnosis if you are planning to take this prescription drug to treat ulcerative colitis. Make sure you take the dosage prescribed by your healthcare provider to avoid Pentasa side effects and to overdose. The following details present dosages that are usually utilized or suggested. Take note that Lialda is manufactured as a tablet delayed release. This means that they are made to have a unique coating that lets them pass through the stomach before completely dissolving. Lialda tablets only have one strength, which is 1.2 g.
Dosage for induction of ulcerative colitis:
Induction of remission means curing the ulcerative colitis until it gets better and completely goes away. The essential dosage for inducing is 2-4 tablets of Lialda per day with food. It is highly recommended that you consume the meds at a similar time every day. Continue drinking the prescribed dosage every day unless your doctor tells you to stop.
Dosage for maintenance of ulcerative colitis :
On another note, the maintenance of ulcerative colitis is consuming Lialda for a prolonged time, even if you are well and don’t experience any symptoms anymore. Maintenance prevents health complication and its symptoms from coming back. The necessary dosage of support is two tablets of Lialda per day with food. It is highly recommended that you consume the meds at a similar time every day. Continue drinking the prescribed dosage every day unless your doctor tells you to stop.
Tell your healthcare provider about every prescription, illegal, over-the-counter, nutritional, herbal, or vitamin-containing supplements drugs you are consuming. Here are the drugs that might severely interact with Mesalamine:
- Milk of Magnesia (magnesium hydroxide) and Alternagel or Amphojel (aluminum hydroxide)
- Polymyxin B
- Aciphex (rabeprazole), Nexium (esomeprazole), Dexilant (dexlansoprazole), and Prevacid (lansoprazole)
- Axid or Axid AR (nizatidine), Tagamet (cimetidine), and Pepcid (famotidine)
- Live varicella vaccine
- MMR II (live measles, rubella vaccine, and mumps)
- Baciim (bacitracin)
Apart from these prescription drugs, alcohol can also interact with Mesalamine. This is because alcohol can irritate your intestines and stomach, and might potentially aggravate your health condition if you’ve already developed ulcerative colitis. As much as the possible limit or avoid alcohol drinking when consuming Mesalamine. Additionally, you should also stay away from drinking grapefruit juice and eating grapefruit while under Mesalamine. This is because grapefruit can interact with the medication since it impedes the ability of the body to dissolve Mesalamine. When this occurs, it could hazardously result in a high accumulation of the meds in the bloodstream.
Warnings and Precautions
This prescription medication has Mesalamine. Refrain from consuming Pentasa, Asacol HD, Delzicol, Lialda, or Apriso if you have an allergic reaction to mesaline and any other ingredients used in these meds. Here are cautions that you should be aware of when taking Lialda and other mesaline-based drugs:
- Coagulation abnormalities, ulfasalazine hypersensitivity, pyloric stenosis, and renal insufficiency.
- Do not take with lactulose or any drug with lower intestinal pH.
- Use with caution if you have severe renal failure or active peptic ulcer disease.
- Even if pericarditis is not common, watch out for breathing problems or chest pain
- Liver failure might happen, especially among patients with underlying live problems
- Rectal issues and low sperm concentration has been discovered among males.
- Worsening of inflammatory bowel disease or colitis after initial therapy
- Renal impairment such as renal failure, minimal change nephropathy, and chronic and acute interstitial nephritis reported.
- Risks among patients with renal impairment or consuming nephrotoxic drugs.
- Acute intolerance syndrome might happen; symptoms might be hard to determine uniquely if it’s from an ulcerative colitis exacerbation; look out for aggravating symptoms; stop using if you suspect acute intolerance syndrome.
- Hypersensitivity reactions like pericarditis and myocarditis discovered; inspect patients right away and stop taking the drug if hypersensitivity reaction is determined.
Pregnancy and Breastfeeding
- Use with caution if you are pregnant, especially if the advantages outrank the risks.
- Mesalamine passes through the breast milk, talk to your doctor before taking the medication of you are lactating.
Overdose and Contraindications
Lialda is considered as an aminosalicylate, and some of the symptoms of salicylate overdosage includes confusion, sweating, headache, drowsiness, hyperventilation, dyspnea, seizures, vomiting, vertigo, diarrhea, and tinnitus. Extreme overdosage can result in unbalanced blood pH and electrolyte, as well as dehydration, hyperthermia, and end-organ hazards. Keep Lialda away from children. In the event of overdose, look for immediate help or call a Poison Control Center right away. Here are the contraindications when taking Lialda:
- Hypersensitivity to salicylates or mesalamine
- Children with flulike symptoms and chickenpox
- Rectal suspension: hypersensitivity to aminosalicylates, salicylates, or any ingredients found in the suppository vehicle
When it comes to the mechanism of action of Lialda, the whole concept is not yet fully understood. However, this drug tends to deliver topical anti-inflammatory impact on the colonic epithelial cells. Generally, the mucosal production of the cyclooxygenase acid metabolites passes through the lipoxygenase and cyclooxygenase passages. An increase can be experienced among those with chronic inflammatory bowel disease, and there is a possibility that the mesalimine can remove inflammation by impeding cyclooxygenase and preventing the production of prostaglandin in the colon.
The recommended dosing when it comes to the induction among adult patients that have active and mild to moderate ulcerative colitis is 2-4 1.2 g Lialda tablets consumed daily with food for an overall regular dose of 4.8 g or 2.4 g. On another note, the suggested dosing for the maintenance of ulcerative colitis is 2 1.2 g of Lialda tablets taken regularly with food for a general dose of 2.4 g. If you are planning to take Lialda, always talk to a healthcare professional such as your doctor or physician first. They will give you appropriate advice diagnosis or treatment for your ulcerative colitis.