Flovent side effects and drug information

Flovent HFA or fluticasone is considered as a corticosteroid. This medication inhibits the release of components in the body that reinforces inflammation.

Flovent is widely used to ward off asthma attacks. However, it won’t cure an asthma attack that started already. Sometimes, it is taken with steroid drugs that are taken orally.

Flovent HFA is prescribed in children at least four years old and adults.

Flovent
Molar mass500.57 g/mol
ChEMBL Id1473
Protein binding91%
ChemSpider ID:392059
PubChem CID444036

Drug Description


Flovent HFA should be used daily to take its full effect
. It doesn’t instantly work and shouldn’t be utilized to treat sudden asthma attacks. In case an asthma attack takes place, turn to your instant-relief inhalers like salbutamol or albuterol as prescribed.

Keep in mind that Flovent doesn’t serve as a rescue medication when asthma attacks occur. Look for immediate medical help if your breathing complications worsen or if your meds for asthma seem not to affect. Besides, if you have an existing allergic reaction to fluticasone or milk proteins, don’t use Flovent.

Side effects

Throat irritation or hoarseness might be experienced. If any of these Flovent HFA side effects continue or worsen, talk to your pharmacist or doctor right away.

Always keep in mind that your doctor was the one who prescribed this specific medication since he/she has decided that the advantages that you’ll get are much higher compared to the risk the side effects might bring you. Call your healthcare provider immediately if any of these severe side effects happen to you: signs of infection (like fever, cough, chills, and prolonged sore throat), easy bleeding or bruising vision problems, white patches in your tongue or mouth, mood or mental changes (including mood swings, depression, feeling agitation), increased urination or thirstiness, and bone pain.

Consequently, Flovent HFA might result in abrupt breathing problems/wheezing right after using it. In case it happens, use your instant-relief inhaler and seek for medical help immediately. Fortunately, an extremely severe allergic reaction to Flovent HFA rarely happens.

You have to look for immediate medical attention if you suspect any signs of a severe allergic reaction, such as swelling or itching (most notably of the tongue, face, and throat), rash, severe dizziness, and breathing problems.

This is not the full list of potential side effects that you might experience when using Flovent. In case you notice other forms of impact that are not provided in the list above, call your healthcare provider right away.

You can also consult your doctor beforehand for medical advice about side effects of Flovent HFA. Moreover, you can report the side effects you experience to the fda at 1-800-fda-1088.

Indication And Dosage

Flovent is explicitly indicated for the maintenance treatment of asthma as a form of prophylactic therapy among patients that are four years old or older. Flovent is also shown for those who need oral corticosteroid therapy to keep asthma at bay. The majority of these patients might be able to lower or remove their need for oral corticosteroid after long-term use.

Furthermore, Flovent HFA must be given through the orally inhaled pathway only among patients that are four years old or older. Right after the inhalation process, it is advised that the patient need to rinse or clean his/her mouth using water without swallowing it to lower the risk of acquiring oropharyngeal candidiasis. Some young patients use a mouthpiece when taking Flovent HFA.

Additionally, individual patients may experience a particular variable time to activate and the degree to relief symptom. The optimum benefit might not be reached for about 1-2 weeks or more extended right after the initial treatment. Once asthma has stabilized, it is highly advisable to titrate the dosage into the lowest effective dose to lower the risk of suffering from any side effects.

If the patient doesn’t react to the medication right away, even after two weeks of undergoing therapy, it is suggested to increase the dosage to offer extra asthma control. But, do not do this without going to a doctor for medical advice. You should also seek advice about side effects of taking Fluticasone for extended periods.

Moreover, the efficacy and safety of Flovent, when used in a higher dosage than recommended, hasn’t been determined yet. The suggested minimum dosage and the maximum suggested dosage of Flovent, according to prior asthma therapy, are listed below.

Previous therapy: Bronchodilators only

Age: 12 years or older

  • Minimum dosage – 88 mcg twice a day
  • Maximum dosage – 440 mcg twice a day

Previous therapy: Inhaled corticosteroids

Age: 12 years or older

  • Minimum dosage – 88 – 220 mcg twice a day
  • Maximum dosage – 440 mcg twice a day

Previous therapy: Oral corticosteroids

Age: 12 years or older

  • Minimum dosage – 440 mcg twice a day
  • Maximum dosage – 880 mcg twice a day

Pediatric Patients

Age: 4-11 years

  • Minimum dosage – 88 mcg twice a day
  • Maximum dosage – 88 mcg twice a day

Pro tip: Prime Flovent HFA before taking it for the first time by spraying it into the air four times. Make sure you sprinkle it away from your face and shake it well for about 5 seconds in between every spray. In case you haven’t used Flovent inhaler for more than a week or you accidentally dropped it, prime it again by shaking it carefully for about 5 seconds and dispense one spray into the air, making sure you keep it away from your face.

Drug Interaction

Using Flovent HFA alongside other prescription medications might interact with the way it works.

It is highly advisable that patients who are using Flovent should let their healthcare professionals know about every other medicine, herbal supplements, dietary supplements, over-the-counter drugs, and illegal drugs that they are taking, in case they do.

Here are the three most common drugs that may potentially interact with their Flovent prescription:

Inhibitors of Cytochrome P450 3A4

Flovent HFA is considered as a substrate of CYP3A4. With this, using potent CYP3A4 inhibitors such as atazanavir, indinavir, ritonavir, itraconazole, clarithromycin, nelfinavir, nefazodone, saquinavir telithromycin, and ketoconazole, with Flovent is not suggested among healthcare professionals since there is a possibility that increased systematic, corticosteroid severe effects might happen.

Ritonavir

According to a drug interaction clinical trial with Flovent HFA nasal spray among healthy participants, the researchers discovered that ritonavir – which is a potent CYP3A4 inhibitor – can increase the plasma fluticasone propionate exposure significantly, leading to the massive decline in serum cortisol concentrations. Apart from this, in the postmarketing usage, there are individual reports of potential drug interactions among patients who are given Flovent and ritonavir altogether, which led to systematic corticosteroid impacts such as adrenal suppression and Cushing’s syndrome.

Ketoconazole

Using orally inhaled Flovent at 1000 mcg alongside ketoconazole at 200 mg once a day led to a 1.9-fold rise in plasma fluticasone propionate exposure and about 45% decline in plasma cortisol area under the curve or AUC. However, it showed zero significant effects on the urinary release of cortisol.

Foods and drinks might also have interactions with Flovent. Stay away from eating grapefruit or drinking grapefruit juice when using Flovent during therapy.

Warnings and Precautions

If you are planning to take Flovent for long-term use, your healthcare provider must monitor you or your kid’s progress via daily check-up. Doing this will help the doctor figure out whether or not the medicine is working correctly and look for side effects.

Even if Flovent lowers the possibility of asthma attacks, it can potentially increase the risk of severe asthma episodes when they hit you. Make sure you carefully read about these certain risks in the leaflet that contains patient information, or you can consult with your pharmacist or doctor about any inquiries or concerns you have.

Always remember that you shouldn’t use Flovent HFA if your asthma episode has already begun. Your doctor will likely prescribe a different medication – like a short-acting inhaler – that you can use if an acute asthma attack kicks in. See to it that you ultimately know how to use the latest meds given to you. If you need instructions, don’t be afraid to talk to your doctor. Furthermore, in case you experience any of the following, call your doctor, and seek medical attention immediately:

  • The symptoms don’t improve or get worse even after using Flovent HFA for two weeks.
  • The short-acting inhaler fails to work.
  • There’s a significant reduction in your peak flow when calculated as instructed by your doctor.

Additionally, Flovent HFA can also result in fungus infection in the throat or mouth. Call your doctor immediately if you notice white patches in your throat or mouth, or you are experience pain when swallowing or eating. Don’t alter your dosage or suddenly discontinue your medication without consulting your doctor.

Using too much Flovent HFA or using it for too long can up your risk of acquiring adrenal gland problems. Contact your doctor if you experience more than one of these signs and symptoms while using Flovent HFA : diarrhea, dizziness or fainting, mental depression, nausea, unusual tiredness or weakness, vomiting, darkening of the skin, lightheadedness, loss of appetite, muscle pain or weakness, or skin rash symptoms.

Moreover, Flovent might also result in paradoxical bronchospasm, which makes your wheezing and breathing worse. Take note that paradoxical bronchospasm can be fatal to your health and might lead to death. Talk to your doctor immediately if you experience breathing difficulty, coughing, wheezing, or shortness of breath after taking these meds. In case you suffer from hives, skin rash, and many other allergic reactions to Flovent, go to your doctor right away. Flovent can also lower down bone mineral density when utilized for a prolonged time. This effect weakens the bones and leads to osteoporosis. In case you have queries about this, consult your doctor. Lastly, Flovent can cause blurred vision, so you might want to talk to your doctor and request for an eye check-up.

Overdose and Contraindications

If you use too much of Flovent, you are at risk for overdose. Contact your doctor or local Poison Control Center or get emergency medical help as soon as possible. If a healthcare professional prescribed Flovent in a medical setting, then overdose is unlikely to happen. But, if the overdosage is inspected, look for immediate medical attention. Moreover, the use of Flovent HFA is contraindicated in these conditions:

  • The major treatment of status asthmaticus and any other severe attacks of asthma that demands comprehensive measures.
  • Active tuberculosis
  • thrush
  • osteoporosis
  • wide-angle glaucoma
  • herpes simplex infection in the eye
  • disease caused by a parasite
  • clouding of the lens of the eye, also known as cataracts
  • lowered calcification or bone density

Clinical Pharmacology of Flovent HFA

Flovent HFA t is established as a synthetic trifluorinated corticosteroid that comes with anti-inflammatory properties. Flovent has been discovered in vitro to show a linking affinity particular for the human glucocorticoid receptor, which is 18 times greater than dexamethasone. It is almost twice the level of beclomethasone17monopropionate (BMP) and active beclomethasone dipropionate metabolite, and more than thrice of budesonide.

Moreover, inflammation is an essential factor when it comes to the pathogenesis of asthma. Flovent HFA is a type of corticosteroid, and these substances have displayed many different effects on various cell groups, resulting in the efficacy in keeping asthma episodes at bay.

As prescription medicine, you should ask your doctor for medical advice before using a fluticasone inhaler like Flovent HFA. You should also consider allergic reactions and read patient information leaflet on fluticasone for possible side effects of Flovent HFA.