Alendronate side effects and drug information

Alendronate is a tablet sold as a generic and brand name medicine. It is available as Binosto and Fosamax. The medication is also available as an effervescent tablet and an oral solution.

ChemSpider ID 2004
PubChem CID 2088
ChemSpider ID 2004
Bioavailability 0.6%
CAS ID 121268-17-5


 The drug is used to cure and prevent osteoporosis among sufferers. It is likewise used among patients with Paget’s disease.

What is Alendronate?

Alendronate is an oral medicine that is available as a tablet, effervescent tablet, and oral solution. The medication is available as a branded drug under the name Binosto and Fosamax. It is also sold as a generic drug. Alendronate is used to cure osteoporosis and Paget’s disease among patients.

Usage of Alendronate

Alendronate is utilized to cure and treat osteoporosis. With this, your bones can turn weak and thin and easily break. The fluticasone medicine can also cure Paget’s disease. In this ailment, the bones can become weak and soft, and eventually, it can become painful and all deformed as well as break easily. Alendronate is a valuable part of any combination therapy, which is potent when coupled with Vitamin D and Calcium supplements.

Alendronate – How It Works

Alendronate is a part of a class of drugs widely known as Bisphosphonates. It is a type of medicine that is a class of medications that work in the same way for muscle cramps. The drugs are used to treat osteoporosis and Paget’s disease. Alendronate works by inhibiting the sudden thinning and breakdown of the bone. This helps improve bone density and helps the bones stay strong and avoid breaking. 

Side Effects

The most common Alendronate side effects are as follows:

If the effects are rather mild, they can go away quickly in a couple of days or weeks. But, if the symptoms are rather severe, or where they are severe, contact your doctor right away.

Alendronate Serious Side Effects

Contact your physician or pharmacist immediately if you experience any of the following serious side effects. Call for emergency medical assistance if you experience any life-threatening symptoms. The serious side effects of Alendronate are as follows:

Erosions or ulcers of the esophagus, the symptoms are as follows:

  • Problem swallowing
  • Heartburns
  • Pain when swallowing
  • Chest pain 
  • Bloody vomit
  • Bloody stools

Bone death of jaw. Here are the symptoms:

  • Loosen teeth
  • Swollen gums
  • Poor healing of the jaw
  • Heavy feeling in the jaw

Unusual breaking of bones in the legs and hips. It can include:

  • Dull pain in the hips
  • Pain in the groin
  • Pain in the thigh area

Hypocalcemia or Low Calcium. The symptoms are:

Dosage and Administration

The dosage information provided here is for the Alendronate tablet. The dosages and drug form may not be added here. The dosage, drug type, and how often the drug is taken will depend on the patients:

  •  Age
  • Condition treated
  • Severity of condition
  • Other medical conditions
  • How the patient reacts to the first dose

Dosage for Osteoporosis

Alendronate Tablet

  •   Tablet
  •  Variants of 5mg, 10mg, 35mg, 40mg, and 70mg

Alendronate Oral Solution

  • 70mg/75ml

Fosamax Tablet

  • Tablet
  • 70 mg strength

Binosto Effervescent Tablet

  • 70 mg strength

Adult Dosage (18 years and older)

  • 70 milligrams once a week or 10 milligrams once a day for treatment
  • 35 milligrams once a week or 5 milligrams once a day

Child Dosage (0–17 years old)

  • The drug should not be used by individuals who are 18 years old and younger.


Different medications require different storage requirements. Always read the product label found on the packaging on how to properly store your Alendronate medication. Keep your medication away from pets and children’s reach at all times. 

Never flush out your medication down the toilet or the drain unless when you are told to do so. Follow proper ways of discarding your medication found on the product packaging when no longer in need or when the product expires. Ask your doctor or pharmacist for proper waste disposal.

Drug Interaction

Alendronate tablet interacts with other medications, vitamins, or herbal supplements. The interaction occurs when a substance changes the way the medicine works. This can be dangerous and hinder the medicines from working well. To avoid any interactions, the physician will manage your medications. Make sure you inform your doctor about all the vitamins, supplements, and medicines you are taking. Check how the drug can interact with something you are taking. 

Here are the drugs that can result in interactions with the Alendronate drug.

Interactions that can heighten side effects:

Taking Alendronate tablet with some drugs can result in more side effects, here is the list of these drugs:

  • Aspirin 
  • NSAIDs or non-steroidal anti-inflammatory drugs 

You can have more upper gastrointestinal side effects like ulcers in our esophagus area. Ask the physician if it is safe for you to take these drugs.

Interactions can make the drug Alendronate less effective. Whenever used with some drugs, it cannot work well to treat your condition. Alendronate in the body can be decreased. Here are some drugs:

  • Iron
  • Magnesium
  • Calcium supplements
  • Antacids

The drugs mentioned above can reduce how the medication absorbs in the body. You should let at least 30 minutes to pass after taking your alendronate another oral medication.

Warnings and Precautions

Food Warning

Take this drug on an empty stomach with a glass of water. Never take with coffee, tea, juice, soda, or mineral water. Doing so can minimize the level of the drug’s potency in the body. It can also heighten certain side effects. Wait at least 30 minuted before you eat or drink something. 

Alcohol Warning

Alcohol can heighten the risk of some side effects on your stomach from taking alendronate. When you intend to drink alcohol, ask your doctor first about it. They can monitor and assess your stomach problems.

Allergy warning

The medication alendronate can lead to some very severe allergic reactions. Symptoms of its side effects can include:

  • Skin rashes
  • Hives
  • Swollen face
  • Swollen lips
  • Swollen tongue
  • Problems breathing

Whenever you experience any allergic reaction, call your doctor or the local poison center in your area without delay. When the symptoms you experience are rather severe, call for emergency medical assistance or dial 911. Never attempt to take this medication ever again if you have ever had any allergic reactions to the drug. Taking it once again can be dangerous and can even lead to death.

Warnings for Certain Users

For those with problems in their esophagus, never take this medication. You will be more likely to have severe side effects like erosions or ulcers in the esophagus area.

For patients with very low calcium blood levels, the physician must provide you calcium medications before starting to take this medicine. Taking Alendronate can only make your health condition worse.

For patients with severe kidney problems, well for those with kidney problems or a history of kidney ailment, you should not be able to clear this from your body. So, you should avoid taking Alendronate altogether.

Pregnant Women

For pregnant women, Alendronate is a regulated category C pregnancy drug. It can only mean two things:

  • There are no enough studies made on humans to be sure how Alendronate can impact the unborn child.
  • The research revealed that in animals, adverse effects occur to the fetus when the mother took the medication.

Always make sure to ask your doctor if you intend to become pregnant or already pregnant. The Alendronate can be used when the potential advantage justifies the risk to the unborn child.

Those who are breastfeeding must consult with their doctor first if they can use Alendronate while breastfeeding. It is not known whether Alendronate can pass into breast milk. When it does, it can lead to some serious side effects to the nursing baby. Ask your doctor or pharmacist if you are breastfeeding a baby and intend to take the medication. They will decide whether you should stop taking the medication altogether. 

Senior citizen patients who have kidney problems or who have weakened kidneys must not take Alendronate too. This medication can lead the body to process certain medicines very slowly. This can result in other problems as the drug will stay in the body for an extended period, and it raises your risk to other side effects.

Pediatric patients are refrained from using this thorazine medication. It is not for use by patients 18 years old and below.

Overdose and Contraindications

When someone you know has overdosed or has severe symptoms like trouble breathing, passing out, or more, call a doctor or pharmacist for immediate medical assistance. You can also call on the poison control center immediately. Residents from the USA can call on their local poison control center for assistance. Severe symptoms of overdose can include persistent nausea, overactive bladder, vomiting, diarrhea, stomach pain, or cramps. Never share this medication with another person even if they have symptoms similar to you. 

The drug has been prescribed for your condition only. Never take any other pain reliever for your urinary tract problem unless you have consulted with your doctor. A different drug may be needed under this circumstance.