Cialis Dosage and Interaction

Cialis or Tadalafil drug is used to treat erectile dysfunction which takes 30 minutes to effect after taking it

Cialis
PubChem CID110635
ChemSpider ID99301
Protein Binding94%
Molar Mass389.404 g/mol
CAS ID171596-29-5

What is Cialis?

Cialis or Tadalafil is used in relaxing the muscles of the blood vessels. Cialis also helps increase blood flow to the specific areas of the body.

Cialis is utilized in the treatment of erectile dysfunction or impotence, as well as the symptoms of an enlarged prostate called benign prostatic hyperplasia.

Adcirca is another brand of Tadalafil that is used in the treatment of pulmonary arterial hypertension. The use of Cialis helps improve the exercise capacity of both men and women.

It is approved for treatment by the United States (U.S.) Food and Drug Administration (FDA) in 2003. It is a yellow tablet, coated in film and with an almond-shape, available in 5, 10, and 20 mg.

Is It Safe to Take Cialis And Drink Alcohol?

Cialis is a safe drug in general but when it is taken with other substances, it may have unsafe effects.

One of the examples is taking it with alcohol. Too much drinking may lead to some serious problems but moderate drinking will not likely cause a problem but how about if you are taking Cialis with it? Here are some things you need to know to stay safe while taking Cialis.

Effects of Taking Cialis and alcohol

If you are drinking alcohol, maybe a glass of wine will not affect Cialis or will cause any harm to your health. But if you are drinking too much and you are taking Cialis then you are getting yourself into huge health trouble.

One of the common health issues resulted from taking Cialis while drinking too much alcohol is orthostatic hypotension. Some of the symptoms are headache, dizziness and fainting, which may further lead to injuries or fractures. Hypotension makes the heart rate fast which may lead to severe heart issues.

This happens because Cialis and alcohol act as vasodilators. Vasodilators are substances known to lower the blood pressure wherein this kind of substance relaxes the blood vessel’s walls allowing it to open wider.

Orthostatic hypotension can likely happen with Cialis more than with other drugs for erectile dysfunction, maybe due to the reason that Cialis remains in the system longer than other ED medications.

How Long Does it Last?

Many people often wonder regarding the effects and how long the effects of Cialis would be for erectile dysfunction. The results of Cialis last longer compared to the effects of Viagra, often reaching up to 36 hours. It means a full 1.5 day.

But there is no need to be alarmed as this does not mean that a person will have an erection for straight 1.5 days. Such will be an emergency. But it is possible to have an erection with the help of Cialis throughout the period of thirty six hours. This is among the reasons why there are some men who would prefer Cialis dosage as it permits spontaneous sexual activity.

In case the erection would last over 4 hours, although it is not painful, it can be considered as a medical emergency. The condition is called priapism. It causes permanent damage to the body tissues that will allow the person to be erect. Those people who are suffering from multiple myeloma, sickle cell anemia, and penile deformities have more tendencies to have a longer time of erection.

How does it Work?

Penile Erection happens when the blood gathers in the penis. This occurs when the blood vessels that carry blood flow to the penis expand, wherein the blood supply is increased. Also, these blood vessels contract when the blood is carried out of the penis. So when the blood gathers in the penis, the erection occurs.

cGMP is a substance in the body that is in charge of the dilation and contraction of the blood vessels that carry blood in and out of the penis. When this substance is destroyed by the enzyme phosphodiesterase type-5 (PDE-5), the erection disappears because the blood vessels get back to their normal size.

So when a man with erectile dysfunction is taking a Cialis, the Tadalafil or Cialis drug blocks the actions of phosphodiesterase type-5 (PDE-5). Since PDE-5 is blocked, it means that there will be an increased level of cGMP in the smooth muscles that help promote vasodilation or the widening of the blood vessels and muscle relaxation when using Tadalafil or Cialis.

It has been found that there are higher levels of PDE-5 in the retina, lungs, and penis. It is also found in the entire body, within the muscles and smooth muscle cells of the blood vessels. Tadalafil or Cialis belongs to the PDE-5 inhibitors class of medicines.

Erectile Dysfunction

For patients with erectile dysfunction, they can take it as needed but it should only be taken once every 24 hours.

The drug will only work provided there is sexual stimulation or a man needs to be sexually aroused.

When a patient is taking a 10mg dose, he should take it 30mins before sexual activity. While the dosage is adjustable and varies depending on the response of the patient, the 20mg dose is the maximum dosage that can be taken as a single dose.

For people who may want to drug Tadalafil or Cialis for sexual activity daily, the starting dose would be 2.5 mg. Then the succeeding dosage of Cialis could be increased up to 5 mg, considering its effectivity and the tolerance of the user. Also, Cialis needs to be taken at the same time every day.

Those people who have been consuming Cialis or Tadalafil as needed have shown a greater and better erectile function than those who are consuming it every day. Its variable explains why the patients are advised only to take it once a day if they hope to get the best of the drug.

The drug remains in the system for 24 hours so the patient is not allowed to take more than one those in 24 hours. If the patient is expected to be sexually active twice a week, he can take 5mg or 2.5mg daily depending on the patient’s response.

Benign Prostatic Hyperplasia

Cialis or Tadalafil is a drug used for the treatment of BPH or benign prostatic hyperplasia. The recommended starting dose of Tadalafil or Cialis for patients who have BPH is 5 mg, and it should be consumed at the same time each day. For those who are undergoing therapy for benign prostatic hyperplasia and are taking finasteride and Cialis, the recommended Cialis Tadalafil dose is 5 mg or 10 mg daily, taken at the same time every day for 26 weeks maximum.

Erectile Dysfunction and Benign Prostatic Hyperplasia

For those who happen to have erectile dysfunction and prostatic hyperplasia, there is no need to worry as they can keep consuming Cialis for the treatment of these conditions. The recommended dose of Cialis for those who want to take it once a day will be 5 mg, 10 mg, or 20 mg. It is important to note that Cialis should not be consumed at the same time every day, irrespective of the sexual activity.

The 10 mg dose or 20 mg of Cialis may be taken for the indicated health conditions, regardless if there is food or none in the stomach. The most important thing is to follow the suggested Cialis doses and stick to it.

But there is some important information that you should know about Cialis.

  • When a person is taking Cialis with nitrate medication, there will be a sudden drop in his blood pressure to a not so safe level. Expect to experience dizziness, fainting, heart attack or stroke.
  • If you need an emergency for your heart problem, you need to inform your doctor that you are taking Cialis. Your healthcare provider must know when did you last take it and the dosage.
  • Some ingredients of Cialis may remain to the body for 2 days or more. But if ever you have kidney or liver problems, or you have other medication, it can stay in your body longer.
  • Physicians should be responsible for discussing with patients the possible problem that the
  • Cialis may affect blood pressure levels.

Even though Cialis is a drug that helps most men, there are also downsides in taking it. Take note that Cialis should only be taken by person ages between 18 and 60. The following are possible side effects.

  • Among the common side effects from patients who are taking Cialis are headaches, back pains, congested nasal, and flushing.
  • Lowering of blood pressure, muscle pains, dyspepsia, and conjunctivitis
  • Vision loss due to the sudden decrease of blood flow to the optic nerve. For people aged 50 and older and with other medical conditions like diabetes, heart problems, high blood pressure, hypertension, the person who smokes, or those who have prior eye problems are at high risk.
  • Other rare side effects are hearing loss, painful erections that may last longer than six hours. Immediately see your doctor if this happens.
  • Cialis is not advisable for persons with angina, or other heart conditions, also for those who have liver disease or kidney problems, bleeding disorder, ulcer, or there is a physical deformity of the penis.
  • Cialis interacts with some drugs like nitrates and it may result in hypotension. It can also interact with other drugs including ketoconazole or ritonavir. Dosage can also be adjusted.
  • The dosage can be reduced especially for men with kidney disease. But for those with serious kidney problems, Cialis is not recommended.
  • Also for men with not serious liver disease, Cialis dosage should be moderated or lowered, while for those with severe kidney disease, it should be avoided.

Bottom Line

Cialis is used as a medication to cure erectile dysfunction and to lessen the indicators of benign prostatic hyperplasia (BPH). One tablet can work up to 36 hours or the lowest dosage can be for daily use even without “plan for sex”.

However, It is also essential to visit a physician or doctor for medical advice about the right starting dose that needs to be taken, whether 5 mg, 10 mg, or 20 mg. Also, it is a must to keep in mind that health professionals are aware of the patient’s medical history more than anyone out there. Therefore, they are the best people who can suggest the best medical advice, the suitable Cialis dose, or for a particular medication that needs to be taken.

Drug Interaction

Cialis or Tadalafil drug is used to treat erectile dysfunction which takes 30 minutes to effect after taking it and known to interact with other medication, supplements, vitamins, or any of the following information below:

  • angiotensin-converting enzyme inhibitors (ACEIs such as enalapril, captopril, ramipril)
  • angiotensin receptor blockers (ARBs such as irbesartan, candesartan, losartan)
  • abiraterone
  • alcohol
  • alpha-blockers (alfuzosin, terazosin, doxazosin,)
  • simeprevir
  • stiripentol
  • tamsulosin
  • telaprevir
  • alprostadil
  • alpha agonists (methyldopa, clonidine)
  • amiodarone
  • antacids (aluminum hydroxide, magnesium hydroxide)
  • clonidine
  • cobicistat
  • aprepitant
  • “azole” antifungals (itraconazole, voriconazole, ketoconazole,)
  • beta-adrenergic blockers (atenolol, sotalol, propranolol,)
  • bicalutamide
  • bosentan
  • calcium channel blockers (amlodipine, nifedipine, diltiazem, verapamil)
  • carbamazepine
  • mifepristone
  • mitotane
  • nefazodone
  • crizotinib
  • cyclosporine
  • dasatinib
  • diuretics (water pills such as hydrochlorothiazide, furosemide, triamterene)
  • imatinib
  • ivacaftor
  • macrolide antibiotics (erythromycin, clarithromycin,)
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs such as delavirdine, etravirine, efavirenz, nevirapine)
  • HIV protease inhibitors (atazanavir, ritonavir, indinavir, saquinavir)
  • hydralazine
  • conivaptan
  • dronedarone
  • enzalutamide
  • grapefruit juice
  • desipramine
  • nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or amyl nitrite “poppers”)
  • norfloxacin
  • other drugs for erectile dysfunction (vardenafil, sildenafil)
  • oxcarbazepine
  • phenobarbital
  • phenytoin
  • primidone
  • rifabutin
  • rifampin
  • Riociguat

If you are consuming any of the medications above, consult your doctor or pharmacist before you take Cialis or Tadalafil drug for your sexual activity to prevent side effects and any possible negative drug interactions that may occur.

Varying on your unique situation, your physician might want you to take or use the following precautions while taking Cialis drug:

  • discontinue receiving one of the prescription drug or medications if you see some risk
  • alter one of the prescription medications to another drug
  • modify the way you consume one or both of the prescription, or
  • continue taking everything as long as the interactions between them do not affect you or no risk at all

Take note that if two prescriptions that you are taking have interactions with Cialis drug (whether 2.5 mg, 10 mg or 20 mg each time each day), it doesn’t necessarily mean that you should discontinue using them. Talk to your doctor for medical advice or information on how you can manage the drug interactions to become more effective and safe at the same time. It can help you in getting the maximum effects of each one. If not, then any adverse effects are possible and are very harmful.

Some medications are not mentioned on the list above, which might also have interactions. Inform your pharmacist or doctor about every over-the-counter drug, prescription, and herbal medicines that you are consuming. Besides this, update them about any supplements that you use or drink. There might be some interactions issue on them that needs to be reported too.

Given that alcohol, street drugs, caffeine, and nicotine from cigarettes can impact the functionality of numerous medications or any drug, you must tell your prescriber if you are using them. Interactions between Cialis and other prescriptions may cause health problems such as hearing loss, back pain, and others so you better ask from a doctor’s medical advice every time. Your health provider needs this information so he can use it as a source of making the final decision regarding your medication.

It’s important to note as well of the proper room temperature you should be keeping Cialis drugs. Information like this is very essential and beneficial for the medication to be more effective. You must not take for granted the risk if this is not used the right way.