Caduet contains a combination of amlodipine and atorvastatin. Atorvastatin is a HMG CoA reductase inhibitor, or “statin.” It reduces levels of “bad” cholesterol (LDL) and triglycerides in the blood, while increasing levels of “good” cholesterol (HDL).
Amlodipine is a calcium channel blocker. Amlodipine relaxes the blood vessels, improving blood flow and making it easier for the heart to pump.
Caduet is used to treat high blood pressure (hypertension) or chest pain (angina), and to lower the risk of stroke, heart attack, and other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors.
Caduet is used in adults and children who are at least 10 years old.
You should not use Caduet if you are allergic to amlodipine (Norvasc) or atorvastatin (Lipitor), if you are pregnant or breast-feeding, or if you have liver disease.
If you have any of these other conditions, your doctor may need to adjust your Caduet dose or order special tests:
- history of liver disease;
- history of kidney disease;
- heart disease;
- a thyroid disorder; or
- if you drink more than 2 alcoholic beverages daily.
In rare cases, Caduet can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).
Tell your doctor about all other medications you use. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them:
- cyclosporine (Gengraf, Neoral, Sandimmune);
- gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide);
- antibiotics such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
- antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
- HIV medications such as ritonavir (Norvir), lopinavir/ritonavir (Kaletra), saquinavir (Invirase), and others; or
- medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others).
FDA pregnancy category X. Caduet can harm an unborn baby or cause birth defects. Do not take Caduet if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking Caduet. Amlodipine and atorvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Caduet.
Get emergency medical help if you have any of these signs of an allergic reaction to Caduet: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medicine and call your doctor at once if you have any of these serious side effects:
- unexplained muscle pain, tenderness, or weakness;
- fever, unusual tiredness, and dark colored urine;
- swelling, weight gain, urinating less than usual or not at all;
- severe drowsiness, feeling like you might pass out;
- fast or pounding heartbeats;
- worsening chest pain;
- chest pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious Caduet side effects may include:
- mild muscle pain;
- mild nausea;
- stomach pain or indigestion;
- joint pain; o
- flushing (warmth or redness in your face).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.