Amitiza Side Effects

Amitiza is a chloride channel activator. It increases fluid secretion in your intestines which increases intestinal muscle movement and helps make it easier to pass stools (bowel movements).

Amitiza is used to treat chronic constipation in adults. It is also used to treat irritable bowel syndrome in women with constipation as the main symptom.
You should not use Amitiza if you have blockage in your digestive tract, or if you have severe diarrhea.

Before using this medication, tell your doctor if you have a history of hernia, gallstones, Crohn’s disease, Hirschsprung’s disease, impacted bowel movement, diverticulitis, polyps, or any other cause for obstruction in your gastrointestinal (digestive) system.

If you have any of these conditions, you may not be able to use Amitiza or you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category C: This medication may be harmful to an unborn baby. Do not use Amitiza without telling your doctor if you are pregnant. You may be asked to have a pregnancy test before you start taking Amitiza. Tell your doctor if you become pregnant during treatment. It is not known if Amitiza passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Amitiza should not be given to a child.

Stop using Amitiza and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe vomiting or diarrhea.

Less serious Amitiza side effects are more likely to occur. Continue using Amitiza and talk with your doctor if you have any of these less serious side effects:

  • nausea, vomiting, mild diarrhea, loss of appetite;
  • stomach pain, bloating, gas;
  • sore throat, cough;
  • headache, dizziness;
  • swelling in your hands, ankles, or feet;
  • joint or muscle pain; or
  • anxiety, cold sweats.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.