Affinitor Side Effects

Afinitor (everolimus) is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.

Afinitor is used to treat advanced kidney cancer. It is usually given after sorafenib (Nexavar) or sunitinib (Sutent) have been tried without successful treatment of symptoms.

Afinitor is also used to treat a type of brain tumor, and a type of kidney tumor that occurs in people with a genetic condition called tuberous sclerosis.

Afinitor is also used to treat non-cancerous (benign) kidney tumors, and certain types of advanced or progressive tumors of the pancreas.

Afinitor is also used to treat advanced hormone-receptor positive, HER2-negative breast cancer in combination with Aromasin (exemestane).

This medication guide provides information about the Afinitor brand of everolimus. Zortress is another brand of everolimus used to prevent organ rejection after a kidney transplant.

You should not use Afinitor if you are allergic to everolimus, sirolimus (Rapamune), tacrolimus (Prograf), or temsirolimus (Torisel).

To make sure you can safely take Afinitor, tell your doctor if you have any of these other conditions:

  • a breathing disorder, such as asthma or COPD (chronic obstructive pulmonary disease);
  • liver disease, or a history of hepatitis B;
  • kidney disease;
  • an active infection;
  • diabetes or high blood sugar; or
  • high cholesterol.

FDA pregnancy category D. Do not take Afinitor if you are pregnant. It could harm the unborn baby. Use effective birth control while you are taking everolimus and for at least 8 weeks after your treatment ends.

Get emergency medical help if you have any of these signs of an allergic reaction to Afinitor: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Afinitor and call your doctor at once if you have a serious side effect such as:

  • new or worsening cough, wheezing, feeling short of breath;
  • stabbing chest pain, cough with yellow or green mucus;
  • seizure (convulsions);
  • white patches or sores inside your mouth or on your lips;
  • swelling, rapid weight gain, urinating less than usual or not at all;
  • fever, chills, sore throat, body aches, flu symptoms, feeling weak or tired;
  • pain or burning when you urinate;
  • pain or fullness in your ear, hearing problems;
  • pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or
  • nausea, pain in your upper stomach, itching, joint pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes).

Less serious Afinitor side effects may include:

  • diarrhea, constipation, mild nausea or vomiting, weight loss;
  • dry skin, acne, mild itching or skin rash;
  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • unusual taste in your mouth;
  • headache; or
  • pain in your arms and legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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