Zoloft (sertraline) is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Zoloft affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.
Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).
Zoloft may also be used for purposes not listed in this medication guide.
Get emergency medical help if you have any of these signs of an allergic reaction to Zoloft: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have a serious side effect such as:
- very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
- agitation, hallucinations, fever, overactive reflexes, tremors;
- nausea, vomiting, diarrhea, loss of appetite, feeling unsteady, loss of coordination; or
- headache, trouble concentrating, memory problems, weakness, fainting, seizure, shallow breathing or breathing that stops.
Less serious Zoloft side effects may include:
- drowsiness, dizziness, tired feeling;
- mild nausea, stomach pain, upset stomach, constipation;
- dry mouth;
- changes in appetite or weight;
- sleep problems (insomnia); or
- decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.