Side Effects of Lotrel


Lotrel contains a combination of amlodipine and benazepril. Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow. Benazepril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water.

Lotrel is used to treat high blood pressure (hypertension). It is usually given after other blood pressure medications have been tried without successful treatment.

Lotrel may also be used for other purposes not listed in this medication guide.

You should not use Lotrel if:

  • you are allergic to amlodipine (Norvasc) or benazepril (Lotensin);
  • you have ever had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction); or
  • you are allergic to any other ACE inhibitor, such as captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

To make sure you can safely take Lotrel, tell your doctor if you have any of these other conditions:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • heart disease or congestive heart failure;
  • diabetes; or
  • if you are on a low-salt diet.

FDA pregnancy category D. Do not use Lotrel if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Lotrel can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking Lotrel. Amlodipine and benazepril can pass into breast milk and may harm a nursing baby. Do not use Lotrel without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction to Lotrel: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Some side effects of Lotrel may not occur until after you have been using the medication for several months.

Call your doctor at once if you have any of these serious side effects:

  • trouble swallowing;
  • chest pain;
  • feeling like you might pass out;
  • urinating more or less than usual, or not at all;
  • swelling, rapid weight gain;
  • fever, chills, sore throat, body aches, flu symptoms; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious Lotrel side effects may include:

  • cough;
  • dizziness, headache;
  • sleep problems (insomnia);
  • flushing (warmth, redness, or tingling under your skin);
  • diarrhea, constipation;
  • muscle pain; or
  • loss of interest in sex.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.


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