Fosamax Side Effects


Fosamax is a prescription medication in pill form known as a Bisphosphonate. It is prescribed for patients who have been diagnosed with pre-osteoporosis, osteoporosis, or osteopenia, all conditions wherein the patient experiences increasingly porous or low density bones. Learn more about Fosamax and Fosamax side effects.

Low bone density can lead to fractures of the hips, leg and arm bones, and fractures of the spine. Bisphosphonates inhibit the breakdown of bones.

Fosamax, approved for patient use in 1996, is a pill taken orally once a week to counter osteoporosis.

Patients are advised to take the pill upon rising in the morning and before eating. It should be swallowed with at least 6 oz of water to aid the delivery of the medication and to reduce the potential of irritation to the esophagus.

For the same reason, patients are advised to remain in an upright position for at least 30 minutes after taking the medicine and until they have eaten their first meal.

Fosamax Side Effects

The use of Bisphosphonate drugs have been associated with the following gastro-intestinal/Fosamax side effects:

  • nausea
  • abdominal cramping
  • diarrhea
  • constipation
  • flatulence
  • ulcers in the esophagus.

Other Fosamax side effects that may occur include:

  • skin rashes
  • eye problems
  • generalized pain in joints, bones and muscles.

A more serious side effect linked to the use of Bisphosphonates is a type of bone disease known as osteonecrosis of the jaw (ONJ), wherein a temporary or permanent loss of blood to bone tissue causes tissue in the jaw and maxillofacial regions to die or collapse.

This collapse is usually associated with an injury including dental work such as a root canal or dental implant, but may appear spontaneously. Because of tissue collapse, the bone is unable to heal properly and may even result in further deterioration.

Symptoms of osteonecrosis of the jaw can include localized pain, numbness, loosening of teeth, infections and bones that begin to be exposed in the mouth. Fosamax users should consult a physician immediately for any of these symptoms.

  • Medical care suppliers should think about whether a patient’s grim musculoskeletal discomfort might be down to bisphosphonate use. The preparations sections of the full prescribing info for all bisphosphonates includes information regarding the capability for grim debilitating bone, joint, and / or muscle agony. Agony is sometimes reported in folks above the age of sixty five years, but a commentary on the patients’ medical and drug treatment history may expose a temporal organisation between the beginning of grim musculoskeletal agony and bisphosphonate use. Prescribers should think about canning the bisphosphonate if extreme pain symptoms happen.
  • Monitor patients who’ve grim musculoskeletal discomfort. Musculoskeletal symptoms may resolve swiftly slowly, or not at all following discontinuation of the bisphosphonate. Alternative factors behind the musculoskeletal discomfort should be considered if symptoms don’t reduce or resolve following withdrawal of the bisphosphonate. * Consider the advantages and risks of bisphosphonate use. Bisphosphonates provide benefit in treating and forestalling osteoporosis and treating hypercalcemia of malignancy, Paget’s illness, and patients with multiple myeloma and bone metastases from solid growths. Info for the patient : Consultants who prescribe bisphosphonates should debate with their patients
  • If you develop serious bone, joint, and / or muscle agony while taking a bisphophonate, speedily contact your GP. Background Info and Information Musculoskeletal agony has been reported in clinical trials of bisphosphonates, though the scale of the pain wasn’t always documented.

The prescribing info for all bisphosphonates contains info in the provisions section about dreadful crippling bone, joint, and / or muscle ( musculoskeletal ) discomfort.

This harsh musculoskeletal pain is in opposition to the acute phase reply, identified by fever, chills, bone agony, myalgias, and arthralgias that often accompanies 1st administration of intravenous bisphosphonates and may happen with initial exposure to once-weekly or once-monthly applications of oral bisphosphonates.

The symptoms related to the acute phase reaction have a tendency to resolve within a couple of days with continued drug use.1, two In 2005, FDA revealed observations from a post-marketing case review of bone, joint, and / or muscle agony of a heavy nature linked with alendronate and risedronate 3.

The range of time to onset of discomfort after beginning alendronate was one day to 52 months (mean = 91 days; median = fourteen days).

As explained in this review, the agony was not isolated to a specific anatomical site. Some patients reported first focal discomfort that grew into diffuse discomfort.
Fosamx Side Effects

In the most harsh cases, discomfort was described as extreme, disabling, or debilitating, and for some patients the agony was so dreadful that they could not to keep on their ordinary activities and needed aids for walking. In a search for a root of the musculoskeletal discomfort, many patients underwent many diagnosis tests with often standard findings.

Agony was treated with a selection of analgesics including opioids. Many patients experienced relief after the bisphosphonate was canned.

While relief was instant after drug discontinuation in some patients, others experienced a slower, partial resolution. The danger factors for and prevalence of dreadful musculoskeletal discomfort linked with bisphosphonates are unknown. FDA is further assessing reports of dreadful musculoskeletal agony connected with bisphosphonate use.

This analysis will take about six months to finish after which FDA will supply to health-care pros any new info useful to the identification and management of dreadful musculoskeletal agony.

This is not a complete list of the Fosamax side effects and others may occur. Call your doctor for medical advice about side effects.

If you think Fosamax is right for you and would like to purchase some at a discounted rate online from an accredited Canadian Pharmacy go to CanadaDrugsDirect.com.


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