name : Tylenol and others
DRUG CLASS AND MECHANISM : Acetaminophen belongs to a class of gear called drugs and antipyretics. The precise mechanism of action of acetaminophen isn’t known. Acetaminophen alleviates discomfort by raising the pain toleration level, that is, by requiring a bigger quantity of discomfort to develop before someone feels it. It decreases fever thru its action on the heat-regulating middle of the brain. Particularly , it tells the center to lower the body’s temperature when the temperature is raised. The FDA authorised acetaminophen in 1951. PRESCRIPTION : No. Common AVAILABLE : Yes. PREPARATIONS : Liquid suspension, chewable capsules, coated caplets, gelcaps, geltabs, and suppositories. Common doses are 325, 5 hundred and 650 mg.
STORAGE : Store capsules and solutions at 70 degrees 15-30C ( 59-86F ). Suppositories should be frozen below 27C ( 80F ). PRESCRIBED FOR : Acetaminophen is utilized for the relief of fever as well as discomforts linked with many conditions.
Acetaminophen mitigates discomfort in mild osseous rheumatism but has no effect on the fundamental soreness, rosiness, and swelling of the joint. If the agony isn’t due to redness, acetaminophen is as useful as aspirin. It is as useful as the non-steroidal antiinflammatory drug ibuprofen ( Motrin ) in relieving the agony of osteoarthritis of the knee. Unless directed by doctor, acetaminophen shouldn’t be used longer than ten days.
DOSING : The oral dose for adults is 325 to 650 mg each four to six hours. The maximum regular dose is four grams. The oral dose for a kid is reliant on the child’s age, and the range is 40-650 mg each four hours. When administered as a suppository, the adult dose is 650 mg each four to six hours. For kids, the dose is 80-325 mg each four to six hours dependent on age. DRUG INTERACTIONS : Acetaminophen is metabolized ( eliminated by conversion to other chemicals ) by the liver. So drugs that increase the action of liver enzymes that metabolize acetaminophen [for example, carbamazepine ( Tegretol ), isoniazid ( INH, Nydrazid, Laniazid ), rifampin ( Rifamate, Rifadin, Rimactane ) ] cut back the levels of acetaminophen and may reduce the action of acetaminophen.
Quantities of acetaminophen larger than the advised doses are lethal to the liver and may cause harsh liver damage. The capability for acetaminophen to hurt the liver is increased when it is mixed with alcohol or drugs that also harm the liver.
Cholestyramine ( Questran ) decreases the effects of acetaminophen by decreasing its assimilation into the body from the intestines. acetaminophen should be administered three to four hours after cholestyramine or an hour before cholestyramine. Acetaminophen doses larger than 2275 mg each day may increase the blood thinning effect of warfarin ( Coumadin ) by an unknown mechanism.
extended administration or massive quantities of acetaminophen must be avoided during warfarin care. PREGNANCY : Acetaminophen is employed in all steps of pregnancy and is the drug of choice for short term treatment of fever and minor agony while carrying a child. NURSING Mas : Acetaminophen is excreted in breast milk in low amounts. Nevertheless acetaminophen use by the nursing mummy seems to be safe. Complications : When used suitably, complications with acetaminophen aren’t common. The most heavy side-effect is liver damage due to giant measures persistent use or concomitant use with alcohol or other drugs that also damage the liver. Lingering alcohol use could also increase the chance of stomach bleeding.
Reference : FDA Prescribing Info .